Natural and synthetic compounds in Ovarian Cancer: A focus on NRF2/KEAP1 pathway

G Tossetta, D Marzioni - Pharmacological Research, 2022 - Elsevier
Among gynecologic malignancies, ovarian cancer is one of the most dangerous, with a high
fatality rate and relapse due to the occurrence of chemoresistance. Many researchers …

Role of NRF2 in ovarian cancer

G Tossetta, S Fantone, E Montanari, D Marzioni… - Antioxidants, 2022 - mdpi.com
Among gynaecologic malignancies, ovarian cancer is one of the most dangerous, with a
high fatality rate and relapse due to the occurrence of chemoresistance. Many researchers …

Targeting the NRF2/KEAP1 pathway in cervical and endometrial cancers

G Tossetta, D Marzioni - European Journal of Pharmacology, 2023 - Elsevier
Cervical and endometrial cancers are among the most dangerous gynaecological
malignancies, with high fatality and recurrence rates due to frequent diagnosis at an …

Role of natural and synthetic compounds in modulating NRF2/KEAP1 signaling pathway in prostate cancer

G Tossetta, S Fantone, D Marzioni, R Mazzucchelli - Cancers, 2023 - mdpi.com
Simple Summary Several studies showed that oxidative stress is involved in cancer
occurrence, development, progression chemoresistance and radio resistance. The nuclear …

Pharmacological applications of Nrf2 inhibitors as potential antineoplastic drugs

P Telkoparan-Akillilar, S Suzen, L Saso - International journal of …, 2019 - mdpi.com
Oxidative stress (OS) is associated with many diseases ranging from cancer to
neurodegenerative disorders. Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) is one of …

Targeting Nrf2 may reverse the drug resistance in ovarian cancer

D Li, X Hong, F Zhao, X Ci, S Zhang - Cancer Cell International, 2021 - Springer
Background Acquired resistance to therapeutic drugs has become an important issue in
treating ovarian cancer. Studies have shown that the prevalent chemotherapy resistance …

Modulation of Nrf2 and NF-κB signaling pathways by naturally occurring compounds in relation to cancer prevention and therapy. Are combinations better than single …

V Krajka-Kuźniak, W Baer-Dubowska - International Journal of Molecular …, 2021 - mdpi.com
Nrf2 (nuclear factor erythroid 2-related factor 2) and NF-κB (nuclear factor–kappa B)
signaling pathways play a central role in suppressing or inducing inflammation and …

Therapeutic targeting of the NRF2 signaling pathway in cancer

P Telkoparan-Akillilar, E Panieri, D Cevik, S Suzen… - Molecules, 2021 - mdpi.com
Cancer is one of the most fatal diseases with an increasing incidence and mortality all over
the world. Thus, there is an urgent need for novel therapies targeting major cancer-related …

Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy

J Sharifi-Rad, V Seidel, M Izabela… - Cell Communication and …, 2023 - Springer
Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism.
The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative …

[HTML][HTML] Controversy about pharmacological modulation of Nrf2 for cancer therapy

L Milkovic, N Zarkovic, L Saso - Redox biology, 2017 - Elsevier
Conventional anticancer therapies such as radiotherapy and chemotherapies are
associated with oxidative stress generating reactive oxygen species (ROS) and reactive …