Cytosine methylation of DNA is a widespread modification of DNA that plays numerous
critical roles. In the yeast Cryptococcus neoformans, CG methylation occurs in transposon …

Epigenetic evolution occurs over million-year timescales in Cryptococcus neoformans and is
mediated by DNMT5, the first maintenance type cytosine methyltransferase identified in the …

DNA methylation is an epigenetic modification with a very long evolutionary history.
However, DNA methylation evolves surprisingly rapidly across eukaryotes. The genome …

The amount of bacterial and archaeal genome sequence and methylome data has greatly
increased over the last decade, enabling new insights into the functional roles of DNA …

Eukaryotic cytosine methylation represses transcription but also occurs in the bodies of
active genes, and the extent of methylation biology conservation is unclear. We quantified …

The widely-cited model of maintenance of DNA methylation at CpG sites implies that DNA
methylation is introduced by the Dnmt3 de novo DNA methyltransferases during early …

DNA modifications are used to regulate gene expression and defend against invading
genetic elements. In eukaryotes, modifications predominantly involve C5-methylcytosine …

Dnmt1 epigenetically propagates symmetrical CG methylation in many eukaryotes. Their
genomes are typically depleted of CG dinucleotides because of imperfect repair of …

DNA methylation is considered a stable epigenetic mark, yet methylation patterns can vary
during differentiation and in diseases such as cancer. Local levels of DNA methylation result …

Cytosine methylation is a com-mon DNA modification found in most eukaryotic organisms
including plants, animals, and fungi (1, 2). The addition of a methyl group to cytosine …