Head and neck cancers (HNC) are a diverse group of aggressive malignancies with high
morbidity and mortality, leading to almost half-million deaths annually worldwide. A better …

Cancer-associated fibroblasts (CAFs) are involved in critical aspects of head and neck
squamous cell carcinoma (HNSCC) pathogenesis, such as the formation of a tumor …

Head and neck squamous cell carcinoma (HNSCC) is among the most severe and complex
malignant diseases with a high level of heterogeneity and, as a result, a wide range of …

Tumor microenvironment (TME) in head and neck squamous cell carcinoma (HNSCC) has a
major influence on disease progression and therapy response. One of the predominant …

Head and neck squamous cell carcinomas (HNSCCs) are amongst the most aggressive,
complex, and heterogeneous malignancies. The standard of care treatments for HNC …

Complex interactions take place during cancer formation and progression. In this regard,
there has been increasing focus on the non-malignant cells that make up the tumour …

Simple Summary As our knowledge of cancer as a complex organ comprising tumor cells as
well as surrounding cells within the microenvironment continues to grow, it is imperative to …

The tumor microenvironment (TME) plays a crucial role in cancer due to its intricate
interactions with the tumor. Within the TME, Cancer Associated Fibroblasts (CAFs) are a …

Introduction Head and neck squamous cell carcinomas (HNSCC) are characterized by
strong cellular and molecular heterogeneity and treatment resistance entailing poor survival …

Simple Summary Cancer-associated fibroblasts (CAFs) are the major cellular component of
the tumor microenvironment and have been shown to stimulate tumor growth, epithelial-to …