[HTML][HTML] Evolution of cancer pharmacological treatments at the turn of the third millennium

L Falzone, S Salomone, M Libra - Frontiers in pharmacology, 2018 - frontiersin.org
The medical history of cancer began millennia ago. Historical findings of patients with
cancer date back to ancient Egyptian and Greek civilizations, where this disease was …

Lessons learned from two decades of anticancer drugs

Z Liu, B Delavan, R Roberts, W Tong - Trends in pharmacological sciences, 2017 - cell.com
Tremendous efforts have been made to elucidate the basis of cancer biology with the aim of
promoting anticancer drug development. Especially over the past 20 years, anticancer drug …

Cancer drug development: The missing links

AB Kunnumakkara, D Bordoloi… - Experimental …, 2019 - journals.sagepub.com
Although better science and technology has been linked with better health care, however,
reality is much different. Although America and most of Europe are equipped with most …

[HTML][HTML] Antitumor drugs and their targets

Z Dembic - Molecules, 2020 - mdpi.com
Through novel methodologies, including both basic and clinical research, progress has
been made in the therapy of solid cancer. Recent innovations in anticancer therapies …

[HTML][HTML] Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics

U Anand, A Dey, AKS Chandel, R Sanyal, A Mishra… - Genes & …, 2023 - Elsevier
Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and
produce aggressive malignancies that causes millions of deaths every year. With the new …

[HTML][HTML] Assessment of the evolution of cancer treatment therapies

M Arruebo, N Vilaboa, B Sáez-Gutierrez, J Lambea… - Cancers, 2011 - mdpi.com
Cancer therapy has been characterized throughout history by ups and downs, not only due
to the ineffectiveness of treatments and side effects, but also by hope and the reality of …

Cancer treatment therapies: traditional to modern approaches to combat cancers

R Kaur, A Bhardwaj, S Gupta - Molecular biology reports, 2023 - Springer
As far as health issues are concerned, cancer causes one out of every six deaths around the
globe. As potent therapeutics are still awaited for the successful treatment of cancer, some …

Discovering novel chemotherapeutic drugs for the third millennium

MD Garrett, P Workman - European Journal of Cancer, 1999 - Elsevier
There is enormous potential for the discovery of innovative cancer drugs with improved
efficacy and selectivity for the third millennium. In this review we show how novel …

Potential anti-cancer drugs commonly used for other indications

V Hanusova, L Skalova, V Kralova… - Current Cancer Drug …, 2015 - ingentaconnect.com
An increasing resistance of mammalian tumor cells to chemotherapy along with the severe
side effects of commonly used cytostatics has raised the urgency in the search for new anti …

Anticancer drug development: the grand challenges

WN Hait - Nature reviews Drug discovery, 2010 - nature.com
Despite vast investment in oncology R&D, the translation of research advances into
medicines that substantially improve the treatment of many cancers remains frustratingly …