While histological changes in microglia have long been recognized as a pathological
feature of Alzheimer's disease (AD), recent genetic association studies have also strongly …

Alzheimer's disease (AD) is currently untreatable, and therapeutic strategies aimed to slow
cognitive decline have not yet been successful. Many of these approaches have targeted the …

Microglia are resident Mϕs of the CNS that play pleiotropic functions in brain development
and homeostasis. Impaired microglial functions are thought to be involved in the onset and …

Alzheimer's disease (AD) is an ever more common neurodegenerative disease among the
elderly, characterized by recurrent neuroinflammation and amyloid beta (Aβ) accumulation …

Alzheimer's disease (AD) is a large and increasing unmet medical need with no disease-
modifying treatment currently available. Genetic evidence from genome-wide association …

Alzheimer's disease (AD) is a progressive neurodegenerative disease and is closely
associated with the accumulation of β-amyloid (Aβ) and neurofibrillary tangles (NFTs). Apart …

Alzheimer's disease (AD) is one of the most common types of age-related dementia
worldwide. In addition to extracellular amyloid plaques and intracellular neurofibrillary …

As prominent immune cells in the central nervous system, microglia constantly monitor the
environment and provide neuronal protection, which are important functions for maintaining …

Microglial cell function is implicated in the etiology of Alzheimer's disease by human
genetics. In this issue of Immunity, Krasemann et al.(2017) describe a gene expression …

After many years of being largely neglected in neurodegenerative disease, the past few
years have seen a turning point in the field's view on the impact of microglia in neurological …