Targeting microglia for the treatment of Alzheimer's Disease
While histological changes in microglia have long been recognized as a pathological
feature of Alzheimer's disease (AD), recent genetic association studies have also strongly …
feature of Alzheimer's disease (AD), recent genetic association studies have also strongly …
[HTML][HTML] Emerging microglia biology defines novel therapeutic approaches for Alzheimer's disease
JW Lewcock, K Schlepckow, G Di Paolo, S Tahirovic… - Neuron, 2020 - cell.com
Alzheimer's disease (AD) is currently untreatable, and therapeutic strategies aimed to slow
cognitive decline have not yet been successful. Many of these approaches have targeted the …
cognitive decline have not yet been successful. Many of these approaches have targeted the …
Microglia in Alzheimer's disease: a target for immunotherapy
Microglia are resident Mϕs of the CNS that play pleiotropic functions in brain development
and homeostasis. Impaired microglial functions are thought to be involved in the onset and …
and homeostasis. Impaired microglial functions are thought to be involved in the onset and …
Microglia in Alzheimer's disease: an unprecedented opportunity as prospective drug target
B Kulkarni, N Cruz-Martins, D Kumar - Molecular Neurobiology, 2022 - Springer
Alzheimer's disease (AD) is an ever more common neurodegenerative disease among the
elderly, characterized by recurrent neuroinflammation and amyloid beta (Aβ) accumulation …
elderly, characterized by recurrent neuroinflammation and amyloid beta (Aβ) accumulation …
Microglial drug targets in AD: opportunities and challenges in drug discovery and development
K Biber, A Bhattacharya, BM Campbell… - Frontiers in …, 2019 - frontiersin.org
Alzheimer's disease (AD) is a large and increasing unmet medical need with no disease-
modifying treatment currently available. Genetic evidence from genome-wide association …
modifying treatment currently available. Genetic evidence from genome-wide association …
Functional and phenotypic diversity of microglia: implication for microglia-based therapies for Alzheimer's disease
YJ Xu, NPB Au, CHE Ma - Frontiers in aging neuroscience, 2022 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disease and is closely
associated with the accumulation of β-amyloid (Aβ) and neurofibrillary tangles (NFTs). Apart …
associated with the accumulation of β-amyloid (Aβ) and neurofibrillary tangles (NFTs). Apart …
Microglia in Alzheimer's disease: a target for therapeutic intervention
G Zhang, Z Wang, H Hu, M Zhao, L Sun - Frontiers in Cellular …, 2021 - frontiersin.org
Alzheimer's disease (AD) is one of the most common types of age-related dementia
worldwide. In addition to extracellular amyloid plaques and intracellular neurofibrillary …
worldwide. In addition to extracellular amyloid plaques and intracellular neurofibrillary …
Novel microglia-based therapeutic approaches to neurodegenerative disorders
As prominent immune cells in the central nervous system, microglia constantly monitor the
environment and provide neuronal protection, which are important functions for maintaining …
environment and provide neuronal protection, which are important functions for maintaining …
A tale of two genes: microglial Apoe and Trem2
Microglial cell function is implicated in the etiology of Alzheimer's disease by human
genetics. In this issue of Immunity, Krasemann et al.(2017) describe a gene expression …
genetics. In this issue of Immunity, Krasemann et al.(2017) describe a gene expression …
Microglia take centre stage in neurodegenerative disease
MT Heneka - Nature Reviews Immunology, 2019 - nature.com
After many years of being largely neglected in neurodegenerative disease, the past few
years have seen a turning point in the field's view on the impact of microglia in neurological …
years have seen a turning point in the field's view on the impact of microglia in neurological …