The T1/ST2 gene encodes, as a result of differential splicing, a cell surface protein
(transmembrane form of T1/ST2, ST2L) and a soluble, secreted, protein (ST2). Here, we …

Abstract T1/ST2L, an IL‐1 receptor homologue, is selectively expressed on murine Th2 cells
and specific anti‐ST2L antibodies can profoundly modulate the Th1/Th2 balance in vivo …

The orphan receptor T1/ST2, a member of the IL-1R family, is preferentially expressed on
the surface of murine Th2 cells. In this study, we analyzed the kinetics and function of T1/ST2 …

T helper cell type 1 (Th1) and 2 (Th2) are central to immune regulation. However, no stable
cell surface marker capable of distinguishing and separating these two subsets of CD4+ …

The ST2 gene, which is specifically induced by growth stimulation, encodes interleukin-1
receptor-related proteins. Using the RT-PCR method, we found that the ST2 gene was …

We have generated mice with a deficiency in T1/ST2 expression to clarify the roles of T1/ST2
in T helper cell type 2 (Th2) responses. Using immunological challenges normally …

The transmembrane form of T1/ST2 (ST2) is a specific marker on murine Th2 cells that have
been generated in vitro, or isolated from sites of allergic type 2 inflammation. Despite the …

ST2 is a member of the interleukin-1 receptor family and is expressed in type-2 T helper
(Th2) cells. Here, we have studied the molecular mechanism responsible for the …

Superantigens are potent activators of the immune system, causing a variety of diseases,
ranging from food poisoning to septic shock. Here, we examined the effects of different toxic …

T helper (Th) cells can be categorized according to their cytokine expression. The differential
induction of Th cells expressing Th1 and/or Th2 cytokines is key to the regulation of both …