Clonally expanded HIV-1 proviruses with 5′-leader defects can give rise to nonsuppressible residual viremia
Background Antiretroviral therapy (ART) halts HIV-1 replication, decreasing viremia to below
the detection limit of clinical assays. However, some individuals experience persistent …
the detection limit of clinical assays. However, some individuals experience persistent …
Identification of genetically intact HIV-1 proviruses in specific CD4+ T cells from effectively treated participants
Latent replication-competent HIV-1 persists in individuals on long-term antiretroviral therapy
(ART). We developed the Full-Length Individual Proviral Sequencing (FLIPS) assay to …
(ART). We developed the Full-Length Individual Proviral Sequencing (FLIPS) assay to …
Viral and host mediators of non-suppressible HIV-1 viremia
Abstract Non-suppressible HIV-1 viremia (NSV) is defined as persistent low-level viremia on
antiretroviral therapy (ART) without evidence of ART non-adherence or significant drug …
antiretroviral therapy (ART) without evidence of ART non-adherence or significant drug …
Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir
JK Bui, MD Sobolewski, BF Keele, J Spindler… - PLoS …, 2017 - journals.plos.org
The major obstacle to curing HIV infection is the persistence of cells with intact proviruses
that can produce replication-competent virus. This HIV reservoir is believed to exist primarily …
that can produce replication-competent virus. This HIV reservoir is believed to exist primarily …
[HTML][HTML] Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure
Antiretroviral therapy fails to cure HIV-1 infection because latent proviruses persist in resting
CD4+ T cells. T cell activation reverses latency, but< 1% of proviruses are induced to …
CD4+ T cells. T cell activation reverses latency, but< 1% of proviruses are induced to …
HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus
EK Halvas, KW Joseph, LD Brandt… - The Journal of …, 2020 - Am Soc Clin Investig
BACKGROUND HIV-1 viremia that is not suppressed by combination antiretroviral therapy
(ART) is generally attributed to incomplete medication adherence and/or drug resistance …
(ART) is generally attributed to incomplete medication adherence and/or drug resistance …
Proviral location affects cognate peptide–induced virus production and immune recognition of HIV-1–infected T cell clones
F Dragoni, AK Kwaa, CC Traut… - The Journal of …, 2023 - Am Soc Clin Investig
BACKGROUND HIV-1–infected CD4+ T cells contribute to latent reservoir persistence by
proliferating while avoiding immune recognition. Integration features of intact proviruses in …
proliferating while avoiding immune recognition. Integration features of intact proviruses in …
The replication-competent HIV reservoir is a genetically restricted, younger subset of the overall pool of HIV proviruses persisting during therapy, which is highly …
A Shahid, S MacLennan, BR Jones… - Journal of …, 2024 - Am Soc Microbiol
Within-host HIV populations continually diversify during untreated infection, and this diversity
persists within infected cell reservoirs during antiretroviral therapy (ART). Achieving a better …
persists within infected cell reservoirs during antiretroviral therapy (ART). Achieving a better …
Defective proviruses rapidly accumulate during acute HIV-1 infection
KM Bruner, AJ Murray, RA Pollack, MG Soliman… - Nature medicine, 2016 - nature.com
Although antiretroviral therapy (ART) suppresses viral replication to clinically undetectable
levels, human immunodeficiency virus type 1 (HIV-1) persists in CD4+ T cells in a latent form …
levels, human immunodeficiency virus type 1 (HIV-1) persists in CD4+ T cells in a latent form …
Measuring the latent reservoir for HIV-1: Quantification bias in near full-length genome sequencing methods
JA White, JT Kufera, N Bachmann, W Dai… - PLoS …, 2022 - journals.plos.org
Antiretroviral therapy (ART) effectively inhibits HIV-1 replication but is not curative due to the
persistence of a latent viral reservoir in resting CD4+ T cells. This reservoir is a major barrier …
persistence of a latent viral reservoir in resting CD4+ T cells. This reservoir is a major barrier …