The endothelium, although only a single layer of cells lining the vascular and lymphatic
systems, contributes in multiple ways to vascular homeostasis. Subsequent to the 1980 …

The vascular endothelium is a multifunctional organ and is critically involved in modulating
vascular tone and structure. Endothelial cells produce a wide range of factors that also …

Abstract Small arterioles (40–150 μm) contribute to the majority of vascular resistance within
organs and tissues. Under resting conditions, the basal tone of these vessels is determined …

The endothelium plays important roles in modulating vascular tone by synthesizing and
releasing a variety of endothelium-derived relaxing factors, including vasodilator …

Diabetes-associated vascular complications are collectively the major clinical problems
facing patients with diabetes and lead to the considerably higher mortality rate than that of …

After the discovery by Furchgott and colleagues in 1980 that the endothelium plays an
obligatory role in acetylcholine-induced vasodilation many investigators have elucidated the …

Robert Furchgott's discovery of the obligatory role that the endothelium plays in the
regulation of vascular tone has proved to be a major advance in terms of our understanding …

In healthy individuals, the vascular endothelium regulates an intricate balance of factors that
maintain vascular homeostasis and normal arterial function. Functional disruption of the …

The endothelium is uniquely positioned at the interface between the blood and the vessel
wall. As such, it performs multiple functions: It is involved in the regulation of coagulation …

Cardiovascular disease is a major complication of diabetes mellitus, and improved
strategies for prevention and treatment are needed. Endothelial dysfunction contributes to …