Ferroptosis and cell death mechanisms in Parkinson's disease

SJ Guiney, PA Adlard, AI Bush, DI Finkelstein… - Neurochemistry …, 2017 - Elsevier
Symptoms of Parkinson's disease arise due to neuronal loss in multiple brain regions,
especially dopaminergic neurons in the substantia nigra pars compacta. Current therapies …

Ferroptosis and its potential role in the physiopathology of Parkinson's Disease

L Mahoney-Sánchez, H Bouchaoui, S Ayton… - Progress in …, 2021 - Elsevier
Parkinson's Disease (PD) is a common and progressive neurodegenerative disorder
characterised by motor impairments as well as non-motor symptoms. While dopamine …

Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential

X Ding, L Gao, Z Han, S Eleuteri, W Shi, Y Shen… - Ageing research …, 2023 - Elsevier
Parkinson's Disease (PD) is characterized by the progressive loss of dopaminergic neurons
in the substantia nigra (SN), leading to motor and non-motor symptoms. While the exact …

[HTML][HTML] Ferroptosis in Parkinson's disease: glia–neuron crosstalk

ZL Wang, L Yuan, W Li, JY Li - Trends in molecular medicine, 2022 - cell.com
Parkinson's disease (PD) is characterized by dopaminergic (DA) neuron loss and the
formation of cytoplasmic protein inclusions. Although the exact pathogenesis of PD is …

Novel druggable mechanism of Parkinson's disease: potential therapeutics and underlying pathogenesis based on ferroptosis

X Jiang, K Wu, XY Ye, T Xie, P Zhang… - Medicinal research …, 2023 - Wiley Online Library
Genetics, age, environmental factors, and oxidative stress have all been implicated in the
development of Parkinson's disease (PD); however, a complete understanding of its …

Iron brain menace: the involvement of ferroptosis in Parkinson disease

KJ Lin, SD Chen, KL Lin, CW Liou, MY Lan… - Cells, 2022 - mdpi.com
Parkinson disease (PD) is the second-most common neurodegenerative disease. The
characteristic pathology of progressive dopaminergic neuronal loss in people with PD is …

Therapeutic insights on ferroptosis in Parkinson's disease

K Thapa, H Khan, N Kanojia, TG Singh, A Kaur… - European journal of …, 2022 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder that alters either motor or non-
motor activities. Dopamine-based medications can help alleviate symptoms at an early …

Ferroptosis as a major factor and therapeutic target for neuroinflammation in Parkinson's disease

CJ Ko, SL Gao, TK Lin, PY Chu, HY Lin - Biomedicines, 2021 - mdpi.com
Mounting evidence suggests that ferroptosis is not just a consequence but also a
fundamental contributor to the development and progression of Parkinson's disease (PD) …

Research progress in the molecular mechanism of ferroptosis in Parkinson's disease and regulation by natural plant products

K Yang, L Zeng, J Zeng, Y Deng, S Wang, H Xu… - Ageing Research …, 2023 - Elsevier
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder of the
central nervous system after Alzheimer's disease. The current understanding of PD focuses …

Ferroptosis: A potential therapeutic target for neurodegenerative diseases

D Vitalakumar, A Sharma… - Journal of Biochemical …, 2021 - Wiley Online Library
Ferroptosis is a newly identified regulated form of cell death, which is thought to play a major
role in neurodegenerative diseases. In this review, we discuss recent studies elucidating the …