Alzheimer's disease is characterized not only by extracellular amyloid plaques and
neurofibrillary tangles, but also by microglia‐mediated neuroinflammation. Recently …

Autophagy is the principal cellular pathway for degradation of long-lived proteins and
organelles and regulates cell fate in response to stress. Recently, autophagy has been …

Accumulation of β-amyloid (Aβ) and resultant inflammation are critical pathological features
of Alzheimer disease (AD). Microglia, a primary immune cell in brain, ingests and degrades …

Autophagy is an intracellular degradation pathway that functions in protein and organelle
turnover in response to starvation and cellular stress. Autophagy is initiated by the formation …

The accumulation of amyloid-β-containing neuritic plaques and intracellular tau protein
tangles are key histopathological hallmarks of Alzheimer's disease (AD). This type of …

Although the process of autophagy has been extensively studied, the mechanisms that
regulate it remain insufficiently understood. To identify novel autophagy regulators, we …

Phagocytosis controls CNS homeostasis by facilitating the removal of unwanted cellular
debris. Accordingly, impairments in different receptors or proteins involved in phagocytosis …

Impairment of the autophagy pathway has been observed during the pathogenesis of
Alzheimer's disease (AD), a neurodegenerative disorder characterized by abnormal …

Autophagy is a highly regulated cellular mechanism for the bulk degradation of cytoplasmic
contents which seems to be implicated in a variety of physiological and pathological …

Microglia play a role in maintaining and resolving brain tissue homeostasis. In pathological
conditions, microglia release pro-inflammatory cytokines and cytotoxic factors, which …