In this study, we evaluate the effect of HO-1 upregulation on blood pressure and cardiac
function in the new model of infarct spontaneous hypertensive rats (ISHR). Male …

Heme oxygenase-1 (HO-1) is a cytoprotective enzyme, which regulates cell proliferation and
has potential antifibrogenic properties. In the present study, we investigated the effects of pre …

Background Up-regulation of HO-1 by genetic manipulation or pharmacological pre-
treatment has been reported to provide benefits in several animal models of myocardial …

P. Lakkisto, E. Palojoki, T. Bäcklund, A. Saraste, I. Tikkanen, L.-M. Voipio-Pulkki and K.
Pulkki. Expression of Heme Oxygenase-1 in Response to Myocardial Infarction in Rats …

The heme-heme oxygenase (HO) system has been implicated in the regulation of vascular
reactivity and blood pressure. This study examines the notion that overexpression of HO …

Background Oxidative stress plays a key role in exacerbating diabetes and cardiovascular
disease. Heme oxygenase-1 (HO-1), a stress response protein, is cytoprotective, but its role …

This study was designed to investigate the effect of increased levels of HO-1 on
hypertension exacerbated by diabetes. Diabetic spontaneously hypertensive rat (SHR) and …

Heme oxygenase (HO) catalyzes the rate-limiting step in the oxidative degradation of
cellular heme that liberates iron, carbon monoxide (CO), and biliverdin. Two distinct HO …

Modern methods of cell and molecular biology, augmented by molecular technology, have
great potential for helping to unravel the complex mechanisms of various diseases. They …

Protective effect of Heme oxygenase-1 (HO-1) induction from hypertension was previously
reported in a diabetic animal model. Here, the effect of HO-1 induction on vascular …