Cellular senescence is a program of cell cycle arrest, apoptosis resistance, and cytokine
release induced by stress exposure in metazoan cells. Landmark studies in laboratory mice …

Cellular senescence response is (i) activated by numerous stresses,(ii) is characterized by a
stable proliferation arrest, and (iii) by a set of specific features. Timely regulated senescence …

Senescence is a mechanism that limits cellular lifespan and constitutes a barrier against
cellular immortalization. To identify new senescence regulatory genes that might play a role …

Senescence is a terminal differentiation program that halts the growth of damaged cells and
must be circumvented for cancer to arise. Here we describe a panel of genetic screens to …

A major goal of aging research is identifying genetic targets that could be used to slow or
reverse aging-changes in the body and extend limits of human lifespan. However, majority …

Cellular senescence is a state of irreversible cellular growth arrest accompanied by distinct
changes in gene expression and the acquisition of a complex proinflammatory secretory …

Bypassing cellular senescence and becoming immortal is a prerequisite step in the
tumorigenic transformation of a cell. It has long been known that loss of a key tumor …

Aging is inevitable, but the lifespan (duration of life) and healthspan (healthy aging) vary
greatly among individuals and across species. Unlocking the secrets behind these …

Background The biological mechanisms that underlie aging have not yet been fully
identified. Senescence, a phenomenon occurring in vitro, limits the number of cell divisions …

Background Progressive neurological dysfunction is a key aspect of human aging. Because
of underlying differences in the aging of mice and humans, useful mouse models have been …