Increased growth factors play a role in wound healing promoted by noninvasive oxygen‐ozone therapy in diabetic patients with foot ulcers

J Zhang, M Guan, C Xie, X Luo… - … medicine and cellular …, 2014 - Wiley Online Library
Management of diabetic foot ulcers (DFUs) is a great challenge for clinicians. Although the
oxygen‐ozone treatment improves the diabetic outcome, there are few clinical trials to verify …

Efficacy of comprehensive ozone therapy in diabetic foot ulcer healing

M Izadi, R Kheirjou, R Mohammadpour… - Diabetes & Metabolic …, 2019 - Elsevier
Background Diabetic foot ulcer is one of the common complications of diabetes disease that
is costly and difficult to treat. This problem can lead to morbidity and even mortality. Ozone is …

Efficacy of ozone–oxygen therapy for the treatment of diabetic foot ulcers

J Wainstein, Z Feldbrin, M Boaz… - Diabetes technology & …, 2011 - liebertpub.com
Background: Diabetic foot ulcers are associated with significant morbidity. Conventional
treatment modalities are often of limited success in promoting complete wound closure. The …

Topical oxygen therapy results in complete wound healing in diabetic foot ulcers

J Yu, S Lu, AM McLaren, JA Perry… - Wound Repair and …, 2016 - Wiley Online Library
Diabetic foot ulcers (DFUs) are a significant problem in an aging population. Fifteen percent
of diabetics develop a DFU over their lifetime, which can lead to potential amputation. The 5 …

[PDF][PDF] Topical wound oxygen therapy in the treatment of severe diabetic foot ulcers: a prospective controlled study

E Blackman, C Moore, J Hyatt, R Railton… - Ostomy/wound …, 2010 - Citeseer
Diabetic foot ulcers (DFU) are common, difficult-to-treat, and prone to complications. A
prospective, controlled study was conducted to: 1) examine the clinical efficacy of a …

Continuous diffusion of oxygen improves diabetic foot ulcer healing when compared with a placebo control: a randomised, double-blind, multicentre study

MQ Niederauer, JE Michalek, Q Liu… - Journal of wound …, 2018 - magonlinelibrary.com
Objective: The aim of this study was to assess whether continuous diffusion of oxygen
improves healing in people receiving treatment for diabetic foot ulcers (DFU). Method: A …

Topical oxygen therapy in the treatment of diabetic foot ulcers: a multicentre, open, randomised controlled clinical trial

TE Serena, NM Bullock, W Cole, J Lantis… - Journal of wound …, 2021 - magonlinelibrary.com
Objectives: Perfusion and blood oxygen levels are frequently insufficient in patients with
hard-to-heal wounds due to poor circulation, vascular disruption and vasoconstriction …

A prospective, randomized, double-blind multicenter study comparing continuous diffusion of oxygen therapy to sham therapy in the treatment of diabetic foot ulcers

MQ Niederauer, JE Michalek… - Journal of diabetes …, 2017 - journals.sagepub.com
Background: Over the past generation, preclinical data have suggested that there is a
potential physiologic benefit to applying oxygen topically to wounds. However, we are …

[HTML][HTML] Topical wound oxygen therapy in the treatment of chronic diabetic foot ulcers

RG Frykberg - Medicina, 2021 - mdpi.com
Oxygen is a critical component of many biological processes and is essential for wound
healing. Chronic wounds are typically characterized as being hypoxic in that the partial …

A multinational, multicenter, randomized, double-blinded, placebo-controlled trial to evaluate the efficacy of cyclical topical wound oxygen (TWO2) therapy in the …

RG Frykberg, PJ Franks, M Edmonds… - Diabetes …, 2020 - Am Diabetes Assoc
OBJECTIVE Topical oxygen has been used for the treatment of chronic wounds for more
than 50 years. Its effectiveness remains disputed due to the limited number of robust high …