Emergence of HIV drug resistance during first-and second-line antiretroviral therapy in resource-limited settings
Introduction Antiretroviral therapy (ART) in resource-limited settings has expanded in the last
decade, reaching> 8 million individuals and reducing AIDS mortality and morbidity …
decade, reaching> 8 million individuals and reducing AIDS mortality and morbidity …
Patterns of HIV-1 drug resistance after first-line antiretroviral therapy (ART) failure in 6 sub-Saharan African countries: implications for second-line ART strategies
RL Hamers, KCE Sigaloff, AM Wensing… - Clinical infectious …, 2012 - academic.oup.com
Background. Human immunodeficiency virus type 1 (HIV-1) drug resistance may limit the
benefits of antiretroviral therapy (ART). This cohort study examined patterns of drug …
benefits of antiretroviral therapy (ART). This cohort study examined patterns of drug …
Emergence of drug resistance in HIV type 1-infected patients after receipt of first-line highly active antiretroviral therapy: a systematic review of clinical trials
R Gupta, A Hill, AW Sawyer… - Clinical infectious …, 2008 - academic.oup.com
Background. Resistance to antiretroviral combination therapy is associated with increased
mortality. Understanding the relative risks of emerging resistance to first-line therapy is of …
mortality. Understanding the relative risks of emerging resistance to first-line therapy is of …
Low-frequency HIV-1 drug resistance mutations and risk of NNRTI-based antiretroviral treatment failure: a systematic review and pooled analysis
Context Presence of low-frequency, or minority, human immunodeficiency virus type 1 (HIV-
1) drug resistance mutations may adversely affect response to antiretroviral treatment (ART) …
1) drug resistance mutations may adversely affect response to antiretroviral treatment (ART) …
Increased resilience to the development of drug resistance with modern boosted protease inhibitor-based highly active antiretroviral therapy
Background. We explore the temporal and regimen-specific changes of HIV-1 drug
resistance in a large cohort of antiretroviral-naive individuals starting highly active …
resistance in a large cohort of antiretroviral-naive individuals starting highly active …
Pretreatment and acquired antiretroviral drug resistance among persons living with HIV in four African countries
TA Crowell, B Danboise, A Parikh… - Clinical Infectious …, 2021 - academic.oup.com
Background Emerging HIV drug resistance (HIVDR) could jeopardize the success of
standardized HIV management protocols in resource-limited settings. We characterized …
standardized HIV management protocols in resource-limited settings. We characterized …
Accumulation of drug resistance and loss of therapeutic options precede commonly used criteria for treatment failure in HIV-1 subtype-C-infected patients
RE Barth, SC Aitken, H Tempelman… - Antiviral …, 2012 - journals.sagepub.com
Background Virological monitoring is essential to identify antiretroviral treatment (ART)
failure, but not widely available. Here, accumulation of resistance and consequences for …
failure, but not widely available. Here, accumulation of resistance and consequences for …
High frequency of clinically significant mutations after first-line generic highly active antiretroviral therapy failure: implications for second-line options in resource …
N Kumarasamy, V Madhavan… - Clinical Infectious …, 2009 - academic.oup.com
Continuation of failed highly active antiretroviral therapy regimens can lead to the
accumulation of mutations that may limit options for second-line treatment. We studied the …
accumulation of mutations that may limit options for second-line treatment. We studied the …
Low-abundance drug-resistant viral variants in chronically HIV-infected, antiretroviral treatment–naive patients significantly impact treatment outcomes
BB Simen, JF Simons, KH Hullsiek… - The Journal of …, 2009 - academic.oup.com
Abstract Background Minor (ie,< 20% prevalence) drug-resistant human immunodeficiency
virus (HIV) variants may go undetected, yet be clinically important Objectives To compare …
virus (HIV) variants may go undetected, yet be clinically important Objectives To compare …
Prevalence of antiretroviral drug resistance mutations in chronically HIV–infected, treatment-naive patients: implications for routine resistance screening before …
RM Novak, L Chen, RD MacArthur… - Clinical infectious …, 2005 - academic.oup.com
Background. The prevalence of drug resistance among persons with newly acquired human
immunodeficiency virus (HIV) infection is well documented. However, it is unclear to what …
immunodeficiency virus (HIV) infection is well documented. However, it is unclear to what …
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