Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease primarily
affecting the motor system of the central nervous system. The aim of this thesis is to evaluate …

Importance of the field: With the emergence of therapeutic candidates for the incurable and
rapidly progressive neurodegenerative condition of amyotrophic lateral sclerosis (ALS), it …

MRI has emerged as one of several urgently needed candidate disease progression
biomarkers for the neurodegenerative disorder amyotrophic lateral sclerosis (ALS), not least …

Amyotrophic lateral sclerosis is a progressive neurodegenerative disease that affects upper
and lower motor neurons. Observational and intervention studies can be tracked using …

Amyotrophic lateral sclerosis (ALS) is a fatal progressive disorder of the central nervous
system affecting the upper and lower motor neurons. It is important to study the specific …

Background: Amyotrophic lateral sclerosis (ALS) is a heterogeneous neurodegenerative
syndrome comprising rapidly progressive weakness, cognitive impairment and death within …

Several quantitative magnetic resonance imaging (MRI) techniques have been proposed to
investigate microstructural tissue changes in amyotrophic lateral sclerosis (ALS) including …

Objective markers of disease sensitive to the clinical activity, symptomatic progression, and
underlying substrates of neurodegeneration are highly coveted in amyotrophic lateral …

Amyotrophic lateral sclerosis (ALS) is a fatal progressive central nervous system disorder
affecting the upper and lower motor neurons. It is important to study the features of the …

Diagnosis, stratification and monitoring of disease progression in amyotrophic lateral
sclerosis currently rely on clinical history and examination. The phenotypic heterogeneity of …