Highlights•Protein–protein interactions are essential for almost all cell processes.•Peptides
are ideal candidates for targeting protein–protein interactions (PPIs).•We survey screening …

Highlights•Cyclic peptides are ideal inhibitors of protein–protein interactions (PPIs), due to
low immunogenicity and large surface area.•Peptide libraries are excellent tools to screen …

Protein–protein interactions (PPI) are a hallmark of cellular signaling. Such interactions
occur abundantly within the cellular milieu and encompass interactions involved in vital …

Protein–protein interactions (PPIs) are tremendously important for the function of many
biological processes. However, because of the structure of many protein–protein interfaces …

Protein–protein interactions (PPIs) have emerged as important and challenging targets in
chemical biology and medicinal chemistry. The main difficulty encountered in the discovery …

Protein–protein interactions (PPIs) are implicated in the majority of cellular processes by
enabling and regulating the function of individual proteins. Thus, PPIs represent high-value …

Protein–protein interactions (PPIs) govern all aspects of cell function and, as such, are a
major target for research and therapeutic intervention. A major rate-limiting step in PPI …

Protein–protein interactions (PPI) are involved in all cellular processes and many represent
attractive therapeutic targets. However, the frequently rather flat and large interaction areas …

Continuing investigations into protein–protein interactions have revealed their key role in
regulating a wide range of cellular processes. Although efforts to modulate these …

Rapid advancements in genomics have brought a better understanding of molecular
mechanisms for various pathologies and identified a number of highly attractive target …