Fibroblasts synthesize the extracellular matrix of connective tissue and play an essential role
in maintaining the structural integrity of most tissues. Researchers have long suspected that …

Tissue fibrosis is the deposition of excessive extracellular matrix and can occur as part of the
body's natural wound healing process upon injury, or as a consequence of diseases such as …

Abstract Purpose of Review Fibroblasts, the major cell population in all connective tissues,
are best known for their role in depositing and maintaining the extracellular matrix. Recently …

Recent work has revealed that fibroblasts are remarkably heterogeneous cells, but the
appropriate lens through which to study this variation (lineage, phenotype, and plasticity) …

Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and
disease by producing complex extracellular matrix and creating signaling niches through …

The inherent plasticity and resiliency of fibroblasts make this cell type a conventional tool for
basic research. But where do they come from, are all fibroblasts the same, and how do they …

Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …

Fibroblasts are important cells for the support of homeostatic tissue function. In inflammatory
diseases such as rheumatoid arthritis and inflammatory bowel disease, fibroblasts take on …

Wound healing disorders are a societal, clinical, and healthcare burden and understanding
and treating them is a major challenge. A particularly important cell type in the wound …

Fibroblasts are the most common cell type of the connective tissues found throughout the
body and the principal source of the extensive extracellular matrix (ECM) characteristic of …