Convenient and efficient routes to construct hybrid molecules containing diterpene alkaloid
lappaconitine and pyrimidine fragments are reported. One route takes place via first …

Diterpenoid alkaloids, originating from the amination of natural tetracyclic diterpenes, have
long interested scientists due to their medicinal uses and infamous toxicity which has limited …

The C 18-diterpenoid alkaloid lappaconitine (LA) is a non-addictive analgesic used in
China. The toxicity (LD 50= 11.7 mg/kg) limits its application. Two series of LA derivatives …

A series of diterpene alkaloid derivatives (1–6) are prepared by reaction of the lappaconitine
(0) with the corresponding organic or inorganic acid. The lappaconitine was isolated from …

Phenanthridinone alkaloids crinasiadine 1 and N‐alkylcrinasiadines 6, 7, 8, 9, 10 have been
synthesized based on palladium‐catalyzed tandem C–C and C–N bond formation starting …

Abstract The indoloquinoline alkaloids cryptolepine (1), neocryptolepine (2), isocryptolepine
(3), and isoneocryptolepine (4) are important tools in traditional medicine. Now, their …

The purpose of this study was to synthetize the focused library of 34 new piperazinamides of
3-methyl-and 3, 3-dimethyl-(2, 5-dioxopyrrolidin-1-yl) propanoic or butanoic acids as …

Alkynones have gained great attention as useful building blocks in organic synthesis. They
have been emerged as key intermediates in the synthesis of various heterocycles. In the …

Indole-based alkaloids are well-known in the literature for their diverse biological properties.
Polysubstituted optically active tetrahydro-β-carboline derivatives functionalized on C-1 …

Cyclohexyl-based chiral auxiliaries can be used effectively in an asymmetric Pictet-Spengler
synthesis of tetrahydroisoquinoline, aporphine and protoberbine alkaloids. Using this …