[HTML][HTML] Circular RNAs: a novel class of functional RNA molecules with a therapeutic perspective

L Santer, C Bär, T Thum - Molecular Therapy, 2019 - cell.com
Circular RNAs (circRNAs) are a subclass of non-coding RNAs that lack free 3′ and 5′
ends and, thus, exist as continuous loop RNAs. Such circular transcripts have been …

Circular RNAs open a new chapter in cardiovascular biology

S Aufiero, YJ Reckman, YM Pinto… - Nature Reviews …, 2019 - nature.com
Circular RNAs (circRNAs) are emerging as a new class of non-coding RNA molecules. This
unusual class of RNA species is generated by a back-splicing event of one or two exons …

The emerging landscape of circular RNA in cardiovascular diseases

M Zhou, JM Yang, X Xiong - Journal of Molecular and Cellular Cardiology, 2018 - Elsevier
Circular RNAs (circRNAs), a large novel type of endogenous transcripts, have become a
new research hotspot in the field of RNA biology. CircRNAs are mainly generated from …

Circles in the heart and cardiovascular system

TB Lim, A Lavenniah, RSY Foo - Cardiovascular Research, 2020 - academic.oup.com
The combination of next-generation sequencing, advanced bioinformatics analysis, and
molecular research has now established circular RNAs (circRNAs) as a heterogeneous …

[HTML][HTML] Circular RNAs: expression, localization, and therapeutic potentials

Q Yang, F Li, AT He, BB Yang - Molecular therapy, 2021 - cell.com
Circular RNAs (circRNAs) are RNAs with a unique circular structure that is generated from
back-splicing processes. These circular molecules were discovered more than 40 years ago …

Circular RNAs in cardiovascular disease: an overview

X Fan, X Weng, Y Zhao, W Chen… - BioMed research …, 2017 - Wiley Online Library
Circular RNA (circRNA), a novel type of endogenous noncoding RNA (ncRNA), has become
a research hotspot in recent years. CircRNAs are abundant and stably exist in creatures …

[HTML][HTML] Circular RNAs: functions and clinical significance in cardiovascular disease

L Zhang, Y Zhang, Y Wang, Y Zhao… - Frontiers in cell and …, 2020 - frontiersin.org
Cardiovascular disease (CVD) causes high morbidity and mortality worldwide. Accumulating
research has indicated the possible roles played by circular RNAs (circRNAs) in the …

circRNA is a potential target for cardiovascular diseases treatment

J Ju, Y Song, X Chen, T Wang, C Liu… - Molecular and Cellular …, 2022 - Springer
Circular RNAs (circRNAs), a novel class of endogenous noncoding RNA, are characterized
by their covalently closed-loop structures without a 5′ cap or a 3′ poly (A) tail. With the …

Circular RNA in cardiovascular disease: Expression, mechanisms and clinical prospects

Y Tang, J Bao, J Hu, L Liu, DY Xu - Journal of cellular and …, 2021 - Wiley Online Library
Circular RNAs (circRNAs) are a group of covalently closed, endogenous, non‐coding RNAs,
which exist widely in human tissues including the heart. Increasing evidence has shown that …

Circular noncoding RNAs as potential therapies and circulating biomarkers for cardiovascular diseases

AS Bayoumi, T Aonuma, J Teoh, Y Tang… - Acta Pharmacologica …, 2018 - nature.com
Recent advancements in genome-wide analyses and RNA-sequencing technologies led to
the discovery of small noncoding RNAs, such as microRNAs (miRs), as well as both linear …