Antibody Recognition of Different Staphylococcus aureus Wall Teichoic Acid Glycoforms

C Di Carluccio, P Soriano-Maldonado, F Berni… - ACS central …, 2022 - ACS Publications
Wall teichoic acids (WTAs) are glycopolymers decorating the surface of Gram-positive
bacteria and potential targets for antibody-mediated treatments against Staphylococcus …

(Automated) Synthesis of Well‐defined Staphylococcus Aureus Wall Teichoic Acid Fragments

S Ali, A Hendriks, R van Dalen… - … A European Journal, 2021 - Wiley Online Library
Wall teichoic acids (WTAs) are important components of the cell wall of the opportunistic
Gram‐positive bacterium Staphylococcus aureus. WTAs are composed of repeating ribitol …

Structural investigation of human S. aureus-targeting antibodies that bind wall teichoic acid

R Fong, K Kajihara, M Chen, I Hotzel, S Mariathasan… - MAbs, 2018 - Taylor & Francis
Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are a growing
health threat worldwide. Efforts to identify novel antibodies that target S. aureus cell surface …

Epitope recognition of a monoclonal antibody raised against a synthetic glycerol phosphate based teichoic acid

F Berni, E Kalfopoulou, AM Gimeno Cardells… - Acs chemical …, 2021 - ACS Publications
Glycerol phosphate (GroP)-based teichoic acids (TAs) are antigenic cell-wall components
found in both enterococcus and staphylococcus species. Their immunogenicity has been …

Synthesis of structure-defined β-1, 4-GlcNAc-modified wall teichoic acids as potential vaccine against methicillin-resistant Staphylococcus aureus

P Shen, L Zheng, X Qin, D Li, Z Zhang, J Zhao… - European Journal of …, 2023 - Elsevier
Methicillin-resistant Staphylococcus aureus (MRSA) is a high priority pathogen due to its life-
threating infections to human health. Development of prophylactic or therapeutic anti-MRSA …

Surface Glycopolymers Are Crucial for In Vitro Anti-Wall Teichoic Acid IgG-Mediated Complement Activation and Opsonophagocytosis of Staphylococcus aureus

JH Lee, NH Kim, V Winstel, K Kurokawa… - Infection and …, 2015 - Am Soc Microbiol
The cell envelopes of many Gram-positive bacteria contain wall teichoic acids (WTAs).
Staphylococcus aureus WTAs are composed of ribitol phosphate (RboP) or glycerol …

Analysis of Staphylococcus aureus wall teichoic acid glycoepitopes by Fourier Transform Infrared Spectroscopy provides novel insights into the staphylococcal …

T Grunert, D Jovanovic, W Sirisarn, S Johler… - Scientific reports, 2018 - nature.com
Surface carbohydrate moieties are essential for bacterial communication, phage-bacteria
and host-pathogen interaction. Most Staphylococcus aureus produce polyribitolphosphate …

Wall teichoic acids prevent antibody binding to epitopes within the cell wall of Staphylococcus aureus

S Gautam, T Kim, E Lester, D Deep… - ACS chemical …, 2016 - ACS Publications
Staphylococcus aureus is a Gram-positive bacterial pathogen that produces a range of
infections including cellulitis, pneumonia, and septicemia. The principle mechanism in …

Glycosylation of wall teichoic acid in Staphylococcus aureus by TarM

G Xia, L Maier, P Sanchez-Carballo, M Li, M Otto… - Journal of Biological …, 2010 - ASBMB
Wall teichoic acid (WTA) glycopolymers are major constituents of cell envelopes in
Staphylococcus aureus and related Gram-positive bacteria with important roles in cell wall …

Pathways and roles of wall teichoic acid glycosylation in Staphylococcus aureus

V Winstel, G Xia, A Peschel - International Journal of Medical Microbiology, 2014 - Elsevier
The thick peptidoglycan layers of Gram-positive bacteria are connected to polyanionic
glycopolymers called wall teichoic acids (WTA). Pathogens such as Staphylococcus aureus …