CYP2J2, a member of the Cytochrome P450 family of enzymes, is the most abundant
epoxygenase in the heart and has multifunctional properties including bioactivation of …

Cytochrome P450 2J2 isoform (CYP2J2) is a drug-metabolizing enzyme that is highly
expressed in adult ventricular myocytes. It is responsible for the bioactivation of arachidonic …

Cytochrome P450 2J2 plays a significant role in the epoxidation of arachidonic acid to
signaling molecules important in cardiovascular events. CYP2J2 also contributes to drug …

Background Canonical studies indicate that cytochrome P450 2E1 (CYP 2E1) plays a critical
role in the metabolism of xenobiotics and ultimately participates in tissue damage. CYP 2E1 …

ABSTRACT Introduction Cytochrome P450s (CYPs) are a superfamily of monooxygenases
with diverse biological roles. CYP2J2 is an isozyme highly expressed in the heart where it …

Cytochrome P450 2J2 (CYP2J2) is a known arachidonic acid (AA) epoxygenase that
mediates the formation of four bioactive regioisomers of cis-epoxyeicosatrienoic acids …

Maladaptive cardiac hypertrophy predisposes one to arrhythmia and sudden death.
Cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) promote anti …

Abstract Cytochrome P450 2 J2 (CYP2J2) is primarily expressed extrahepatically and is the
predominant epoxygenase in human cardiac tissues. This highlights its key role in the …

Cytochrome P450 (CYP) represents a large family of enzymes that catalyze the oxidation of
endogenous and exogenous compounds. The functions of CYP enzymes in the metabolism …

Cardiovascular disease (CVD) is a human health crisis that remains the leading cause of
death worldwide. The cytochrome P450 (CYP) class of enzymes are key metabolizers of …