Cancer is a disease that involves impaired genome stability with a high mortality index
globally. Since its discovery, many have searched for effective treatment, assessing different …

An efficient one-pot reaction for the synthesis of oxoaporphine alkaloids has been
developed. Twenty-three compounds of oxoaporphine alkaloids were prepared and …

A series of novel oxoisoaporphine alkaloid derivatives, 9-aminoalkanamido-1-
azabenzanthrone (general formula Ar–NHCO (CH2) nNR2, Ar= 1-azabenzanthrone, n= 1, 2 …

Sampangine is a plant-derived copyrine alkaloid extracted from the stem bark of Cananga
odorata. This azaoxoaporphine alkaloid primarily exhibits antifungal and antimycobacterial …

Oxoisoaporphine alkaloids are a family of oxoisoquinoline‐derived alkaloids that were first
isolated from the rhizome of Menispermum dauricum DC.(Menispermaceae). It has been …

Aporphinoids form an important group of plant secondary metabolites. Some of these
compounds are used for a long time in traditional medicine for the treatment of various …

A series of oxoisoaporphine derivatives with topoisomerase I inhibition and cytotoxic
activities. Among them, compound 14 showed the most potent cytotoxic activity against all …

Cancer is the second leading cause of mortality and has resulted in about 9.6 million deaths
around the world in 2018. Cancer-caused deaths are expected to be 11.5 million by 2030 all …

Sampangine is an azaoxoaporphine alkaloid with interesting biological activities.
Elucidating the mode of action of sampangine is a topic of continuous research. Recently …

A series of group-10 metal complexes 1–14 of oxoisoaporphine derivatives were designed
and synthesized. 1–14 were more selectively cytotoxic to Hep-G2 cells comparing with …