Genomic profiling of Sézary syndrome identifies alterations of key T cell signaling and differentiation genes

L Wang, X Ni, KR Covington, BY Yang, J Shiu… - Nature …, 2015 - nature.com
Sézary syndrome is a rare leukemic form of cutaneous T cell lymphoma characterized by
generalized redness, scaling, itching and increased numbers of circulating atypical T …

The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome

AC da Silva Almeida, F Abate, H Khiabanian… - Nature …, 2015 - nature.com
Sézary syndrome is a leukemic and aggressive form of cutaneous T cell lymphoma (CTCL)
resulting from the malignant transformation of skin-homing central memory CD4+ T cells …

Candidate driver genes involved in genome maintenance and DNA repair in Sézary syndrome

WJ Woollard, V Pullabhatla, A Lorenc… - Blood, The Journal …, 2016 - ashpublications.org
Sézary syndrome (SS) is a leukemic variant of cutaneous T-cell lymphoma (CTCL) and
represents an ideal model for study of T-cell transformation. We describe whole-exome and …

Sezary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3

N Booken, A Gratchev, J Utikal, C Weiss, X Yu… - Leukemia, 2008 - nature.com
Sezary syndrome (SS) is a rare, aggressive CD4+ cutaneous T-cell lymphoma (CTCL);
molecular traits differentiating SS from nonleukemic mycosis fungoides (MF) and from …

Novel and highly recurrent chromosomal alterations in Sezary syndrome

MH Vermeer, R van Doorn, R Dijkman, X Mao… - Cancer research, 2008 - AACR
This study was designed to identify highly recurrent genetic alterations typical of Sézary
syndrome (Sz), an aggressive cutaneous T-cell lymphoma/leukemia, possibly revealing …

Genomic analyses reveal recurrent mutations in epigenetic modifiers and the JAK–STAT pathway in Sézary syndrome

MJ Kiel, AA Sahasrabuddhe, DCM Rolland… - Nature …, 2015 - nature.com
Sézary syndrome (SS) is an aggressive leukaemia of mature T cells with poor prognosis and
limited options for targeted therapies. The comprehensive genetic alterations underlying the …

Identification of key regions and genes important in the pathogenesis of sezary syndrome by combining genomic and expression microarrays

E Caprini, C Cristofoletti, D Arcelli, P Fadda… - Cancer research, 2009 - AACR
In this study, we used single nucleotide polymorphism and comparative genomic
hybridization array to study DNA copy number changes and loss of heterozygosity for 28 …

[HTML][HTML] Identification of gene mutations and fusion genes in patients with Sézary syndrome

A Prasad, R Rabionet, B Espinet, L Zapata… - Journal of Investigative …, 2016 - Elsevier
Sézary syndrome is a leukemic form of cutaneous T-cell lymphoma with an aggressive
clinical course. The genetic etiology of the disease is poorly understood, with chromosomal …

Single-cell heterogeneity in Sézary syndrome

TB Buus, A Willerslev-Olsen, S Fredholm… - Blood …, 2018 - ashpublications.org
Sézary syndrome (SS) is an aggressive leukemic variant of cutaneous T-cell lymphoma
(CTCL) with a median life expectancy of less than 4 years. Although initial treatment …

Molecular cytogenetic characterization of Sezary syndrome

X Mao, DM Lillington, B Czepulkowski… - Genes …, 2003 - Wiley Online Library
Sézary syndrome (SS) is a rare form of erythrodermic cutaneous T‐cell lymphoma with
hematological involvement and a poor prognosis. At present little is known about the …