Genomic profiling of Sézary syndrome identifies alterations of key T cell signaling and differentiation genes
Sézary syndrome is a rare leukemic form of cutaneous T cell lymphoma characterized by
generalized redness, scaling, itching and increased numbers of circulating atypical T …
generalized redness, scaling, itching and increased numbers of circulating atypical T …
The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome
Sézary syndrome is a leukemic and aggressive form of cutaneous T cell lymphoma (CTCL)
resulting from the malignant transformation of skin-homing central memory CD4+ T cells …
resulting from the malignant transformation of skin-homing central memory CD4+ T cells …
Candidate driver genes involved in genome maintenance and DNA repair in Sézary syndrome
WJ Woollard, V Pullabhatla, A Lorenc… - Blood, The Journal …, 2016 - ashpublications.org
Sézary syndrome (SS) is a leukemic variant of cutaneous T-cell lymphoma (CTCL) and
represents an ideal model for study of T-cell transformation. We describe whole-exome and …
represents an ideal model for study of T-cell transformation. We describe whole-exome and …
Sezary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3
Sezary syndrome (SS) is a rare, aggressive CD4+ cutaneous T-cell lymphoma (CTCL);
molecular traits differentiating SS from nonleukemic mycosis fungoides (MF) and from …
molecular traits differentiating SS from nonleukemic mycosis fungoides (MF) and from …
Novel and highly recurrent chromosomal alterations in Sezary syndrome
MH Vermeer, R van Doorn, R Dijkman, X Mao… - Cancer research, 2008 - AACR
This study was designed to identify highly recurrent genetic alterations typical of Sézary
syndrome (Sz), an aggressive cutaneous T-cell lymphoma/leukemia, possibly revealing …
syndrome (Sz), an aggressive cutaneous T-cell lymphoma/leukemia, possibly revealing …
Genomic analyses reveal recurrent mutations in epigenetic modifiers and the JAK–STAT pathway in Sézary syndrome
Sézary syndrome (SS) is an aggressive leukaemia of mature T cells with poor prognosis and
limited options for targeted therapies. The comprehensive genetic alterations underlying the …
limited options for targeted therapies. The comprehensive genetic alterations underlying the …
Identification of key regions and genes important in the pathogenesis of sezary syndrome by combining genomic and expression microarrays
E Caprini, C Cristofoletti, D Arcelli, P Fadda… - Cancer research, 2009 - AACR
In this study, we used single nucleotide polymorphism and comparative genomic
hybridization array to study DNA copy number changes and loss of heterozygosity for 28 …
hybridization array to study DNA copy number changes and loss of heterozygosity for 28 …
[HTML][HTML] Identification of gene mutations and fusion genes in patients with Sézary syndrome
Sézary syndrome is a leukemic form of cutaneous T-cell lymphoma with an aggressive
clinical course. The genetic etiology of the disease is poorly understood, with chromosomal …
clinical course. The genetic etiology of the disease is poorly understood, with chromosomal …
Single-cell heterogeneity in Sézary syndrome
Sézary syndrome (SS) is an aggressive leukemic variant of cutaneous T-cell lymphoma
(CTCL) with a median life expectancy of less than 4 years. Although initial treatment …
(CTCL) with a median life expectancy of less than 4 years. Although initial treatment …
Molecular cytogenetic characterization of Sezary syndrome
X Mao, DM Lillington, B Czepulkowski… - Genes …, 2003 - Wiley Online Library
Sézary syndrome (SS) is a rare form of erythrodermic cutaneous T‐cell lymphoma with
hematological involvement and a poor prognosis. At present little is known about the …
hematological involvement and a poor prognosis. At present little is known about the …
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- cell signaling genomic profiling
- gene mutations sézary syndrome
- cell lymphoma sézary syndrome
- chromosomal alterations sézary syndrome
- genomic analyses sézary syndrome
- stat pathway sézary syndrome
- epigenetic modifiers sézary syndrome
- dna repair sézary syndrome
- marker molecules sézary syndrome
- fusion genes sézary syndrome
- gene signature sézary syndrome
- recurrent mutations sézary syndrome
- genome maintenance sézary syndrome
- mutational landscape sézary syndrome
- molecular heterogeneity sézary syndrome