Prosenescence therapy has recently emerged as a novel therapeutic approach for treating
cancer. However, this concept is challenged by conflicting evidence showing that the …

Tumor-associated macrophages (TAMs) represent a major component of the tumor
microenvironment supporting tumorigenesis. TAMs re-education has been proposed as a …

Irreversible cell growth arrest, a process termed cellular senescence, is emerging as an
intrinsic tumor suppressive mechanism. Oncogene-induced senescence is thought to be …

Metastases account for most cancer-related deaths, yet the mechanisms underlying
metastatic spread remain poorly understood. Recent evidence demonstrates that senescent …

Mutations in PTEN activate the phosphoinositide 3-kinase (PI3K) signalling network, leading
to many of the characteristic phenotypic changes of cancer. However, the primary effects of …

Increasing clinical evidence has demonstrated that the deletion or mutation of tumor
suppressor genes such as the gene-encoding phosphatase and tensin homolog deleted on …

In addition to promoting various forms of cell death, most conventional anti-tumor therapies
also promote senescence. There is now extensive evidence that therapy-induced …

Background Accumulating evidence shows that tumor cell–specific genomic changes can
influence the cross talk between cancer cells and the surrounding tumor microenvironment …

Prostate cancer is the most prevalent cancer in males, and treatment options are limited for
advanced forms of the disease. Loss of the PTEN and TP53 tumor suppressor genes is …

Aberrant activation of oncogenes or loss of tumour suppressor genes opposes malignant
transformation by triggering a stable arrest in cell growth, which is termed cellular …