New molecular therapies for the treatment of hearing loss

Y Ma, AK Wise, RK Shepherd… - Pharmacology & …, 2019 - Elsevier
An estimated 466 million people suffer from hearing loss worldwide. Sensorineural hearing
loss is characterized by degeneration of key structures of the sensory pathway in the …

Recent Therapeutic Progress and Future Perspectives for the Treatment of Hearing Loss

J Lye, DS Delaney, FK Leith, VS Sardesai… - Biomedicines, 2023 - mdpi.com
Up to 1.5 billion people worldwide suffer from various forms of hearing loss, with an
additional 1.1 billion people at risk from various insults such as increased consumption of …

Therapeutics of hearing loss: expectations vs reality

O Atar, KB Avraham - Drug Discovery Today, 2005 - Elsevier
With the completion of the sequencing of the human genome, the field of medicine is
undergoing a dramatic and fundamental change. The identification of our genes and the …

New treatment options for hearing loss

U Müller, PG Barr-Gillespie - Nature reviews Drug discovery, 2015 - nature.com
Hearing loss is the most common form of sensory impairment in humans and affects more
than 40 million people in the United States alone. No drug-based therapy has been …

Toward cochlear therapies

J Wang, JL Puel - Physiological reviews, 2018 - journals.physiology.org
Sensorineural hearing impairment is the most common sensory disorder and a major health
and socio-economic issue in industrialized countries. It is primarily due to the degeneration …

Advances in molecular and cellular therapies for hearing loss

MS Hildebrand, SS Newton, SP Gubbels, AM Sheffield… - Molecular Therapy, 2008 - cell.com
Development of effective therapeutics for hearing loss has proven to be a slow and difficult
process, evidenced by the lack of restorative medicines and technologies currently available …

Recent advances and future challenges in gene therapy for hearing loss

AE Amariutei, JY Jeng… - Royal Society Open …, 2023 - royalsocietypublishing.org
Hearing loss is the most common sensory deficit experienced by humans and represents
one of the largest chronic health conditions worldwide. It is expected that around 10% of the …

Cochlear gene therapy for sensorineural hearing loss: current status and major remaining hurdles for translational success

W Zhang, SM Kim, W Wang, C Cai, Y Feng… - Frontiers in molecular …, 2018 - frontiersin.org
Sensorineural hearing loss (SNHL) affects millions of people. Genetic mutations play a large
and direct role in both congenital and late-onset cases of SNHL (eg, age-dependent hearing …

Gene therapy for hearing loss

R Omichi, SB Shibata, CC Morton… - Human molecular …, 2019 - academic.oup.com
Sensorineural hearing loss (SNHL) is the most common sensory disorder. Its underlying
etiologies include a broad spectrum of genetic and environmental factors that can lead to …

Emerging gene therapies for genetic hearing loss

H Ahmed, O Shubina-Oleinik, JR Holt - … of the Association for Research in …, 2017 - Springer
Gene therapy, or the treatment of human disease using genetic material, for inner ear
dysfunction is coming of age. Recent progress in developing gene therapy treatments for …