New molecular therapies for the treatment of hearing loss
An estimated 466 million people suffer from hearing loss worldwide. Sensorineural hearing
loss is characterized by degeneration of key structures of the sensory pathway in the …
loss is characterized by degeneration of key structures of the sensory pathway in the …
Recent Therapeutic Progress and Future Perspectives for the Treatment of Hearing Loss
J Lye, DS Delaney, FK Leith, VS Sardesai… - Biomedicines, 2023 - mdpi.com
Up to 1.5 billion people worldwide suffer from various forms of hearing loss, with an
additional 1.1 billion people at risk from various insults such as increased consumption of …
additional 1.1 billion people at risk from various insults such as increased consumption of …
Therapeutics of hearing loss: expectations vs reality
O Atar, KB Avraham - Drug Discovery Today, 2005 - Elsevier
With the completion of the sequencing of the human genome, the field of medicine is
undergoing a dramatic and fundamental change. The identification of our genes and the …
undergoing a dramatic and fundamental change. The identification of our genes and the …
New treatment options for hearing loss
U Müller, PG Barr-Gillespie - Nature reviews Drug discovery, 2015 - nature.com
Hearing loss is the most common form of sensory impairment in humans and affects more
than 40 million people in the United States alone. No drug-based therapy has been …
than 40 million people in the United States alone. No drug-based therapy has been …
Toward cochlear therapies
J Wang, JL Puel - Physiological reviews, 2018 - journals.physiology.org
Sensorineural hearing impairment is the most common sensory disorder and a major health
and socio-economic issue in industrialized countries. It is primarily due to the degeneration …
and socio-economic issue in industrialized countries. It is primarily due to the degeneration …
Advances in molecular and cellular therapies for hearing loss
MS Hildebrand, SS Newton, SP Gubbels, AM Sheffield… - Molecular Therapy, 2008 - cell.com
Development of effective therapeutics for hearing loss has proven to be a slow and difficult
process, evidenced by the lack of restorative medicines and technologies currently available …
process, evidenced by the lack of restorative medicines and technologies currently available …
Recent advances and future challenges in gene therapy for hearing loss
AE Amariutei, JY Jeng… - Royal Society Open …, 2023 - royalsocietypublishing.org
Hearing loss is the most common sensory deficit experienced by humans and represents
one of the largest chronic health conditions worldwide. It is expected that around 10% of the …
one of the largest chronic health conditions worldwide. It is expected that around 10% of the …
Cochlear gene therapy for sensorineural hearing loss: current status and major remaining hurdles for translational success
W Zhang, SM Kim, W Wang, C Cai, Y Feng… - Frontiers in molecular …, 2018 - frontiersin.org
Sensorineural hearing loss (SNHL) affects millions of people. Genetic mutations play a large
and direct role in both congenital and late-onset cases of SNHL (eg, age-dependent hearing …
and direct role in both congenital and late-onset cases of SNHL (eg, age-dependent hearing …
Gene therapy for hearing loss
R Omichi, SB Shibata, CC Morton… - Human molecular …, 2019 - academic.oup.com
Sensorineural hearing loss (SNHL) is the most common sensory disorder. Its underlying
etiologies include a broad spectrum of genetic and environmental factors that can lead to …
etiologies include a broad spectrum of genetic and environmental factors that can lead to …
Emerging gene therapies for genetic hearing loss
H Ahmed, O Shubina-Oleinik, JR Holt - … of the Association for Research in …, 2017 - Springer
Gene therapy, or the treatment of human disease using genetic material, for inner ear
dysfunction is coming of age. Recent progress in developing gene therapy treatments for …
dysfunction is coming of age. Recent progress in developing gene therapy treatments for …