Many aspects of cognition and behaviour are regulated by noradrenergic projections to the
forebrain originating from the locus coeruleus, acting through alpha and beta …

Noradrenergic dysfunction contributes to cognitive impairment in Alzheimer's Disease (AD)
and Parkinson's Disease (PD). Conventional therapeutic strategies seek to enhance …

Norepinephrine released by the locus coeruleus modulates cellular processes and synaptic
transmission in the central nervous system through its actions at a number of pre‐and …

Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

The brain noradrenergic system supplies the neurotransmitter norepinephrine throughout
the brain via widespread efferent projections, and plays a pivotal role in modulating …

Mood, attention and motivation co-vary with activity in the neuromodulatory systems of the
brain to influence behaviour. These psychological states, mediated by neuromodulators …

The noradrenaline (norepinephrine) system exerts profound influences on cognition via
ascending projections to the forebrain, mostly originating from the locus coeruleus. This …

The early demonstration of the neurotransmitter role of norepinephrine (NE) within the brain
stimulated intense study of its functions over the subsequent three decades. A large majority …

The locus coeruleus (LC), the major origin of noradrenergic modulation of the central
nervous system, innervates extensive areas throughout the brain and is implicated in a …

Although resting tremor, cogwheel rigidity, hypokinesia/bradykinesia and postural instability
usually dominate the clinical picture of sporadic Parkinson's disease (PD), both clinical and …