Suppression of interactions between prostate tumor cell‐surface integrin and endothelial ICAM‐1 by simvastatin inhibits micrometastasis

B AL‐Husein, A Goc… - Journal of cellular …, 2013 - Wiley Online Library
Cancer micrometastasis relies on the ability of cancer cells to secrete angiogenic
modulators, to interact with the vascular endothelium, and to overcome the resistance …

Endothelial cells enhance prostate cancer metastasis via IL-6→ androgen receptor→ TGF-β→ MMP-9 signals

X Wang, SO Lee, S Xia, Q Jiang, J Luo, L Li… - Molecular cancer …, 2013 - AACR
Although the potential roles of endothelial cells in the microvascules of prostate cancer
during angiogenesis have been documented, their direct impacts on the prostate cancer …

Atorvastatin inhibited Rho-associated kinase 1 (ROCK1) and focal adhesion kinase (FAK) mediated adhesion and differentiation of CD133+ CD44+ prostate cancer …

S Rentala, R Chintala, M Guda, M Chintala… - Biochemical and …, 2013 - Elsevier
Prostate cancer has become a global health concern and is one of the leading causes of
cancer death of men after lung and gastric cancers. It has been suggested that the 3-hydroxy …

Simvastatin modulates the adhesion and growth of hepatocellular carcinoma cells via decrease of integrin expression and ROCK

B Relja, F Meder, M Wang… - International …, 2011 - spandidos-publications.com
Hepatocellular carcinoma (HCC) has become a global health concern and is one of the
leading causes of cancer death after lung and gastric cancers. It has been suggested that …

β3 integrins facilitate matrix interactions during transendothelial migration of PC3 prostate tumor cells

X Wang, AM Ferreira, Q Shao, DW Laird… - The Prostate, 2005 - Wiley Online Library
BACKGROUND β3 integrins play a role in metastatic progression of prostate cancer by
mediating adhesion of cancer cells to endothelium and migration through extracellular …

Integrin α2β1 inhibition attenuates prostate cancer cell proliferation by cell cycle arrest, promoting apoptosis and reducing epithelial–mesenchymal transition

Z Salemi, R Azizi, F Fallahian… - Journal of Cellular …, 2021 - Wiley Online Library
Integrin α2β1 plays an important role in cellular migration and metastasis processes
associated with prostate cancer. The aim of this study was to assess whether selective …

Reorganization of the integrin α2 subunit controls cell adhesion and cancer cell invasion in prostate cancer

S Van Slambrouck, AR Jenkins… - International …, 2009 - spandidos-publications.com
The mechanisms of invasion and metastasis are poorly understood. Our previous studies
demonstrated that cancer cell invasion may result from reorganization of membrane …

The blockage of downstream P2Y2 receptor signaling inhibits the prostate cancer cell adhesion to endothelial cells

TC Cardoso, MA Rocha, MMLV Monteiro, VS Alves… - Life Sciences, 2022 - Elsevier
Aims Prostate cancer is the second most frequently malignancy in men worldwide. Most
deaths are caused by metastasis, and tumor cell dissemination involves the interaction with …

[HTML][HTML] Integrin α2β1 decelerates proliferation, but promotes survival and invasion of prostate cancer cells

M Ojalill, M Parikainen, P Rappu, E Aalto, J Jokinen… - Oncotarget, 2018 - ncbi.nlm.nih.gov
High expression level of integrin α2β1 is a hallmark of prostate cancer stem cell like cells.
The role of this collagen receptor is controversial since it is down regulated in poorly …

[HTML][HTML] Simvastatin blocks TGF-β1-induced epithelial-mesenchymal transition in human prostate cancer cells

F Xie, J Liu, C Li, Y Zhao - Oncology Letters, 2016 - spandidos-publications.com
In recent years, the use of statins has been reported to be associated with a reduced risk of
prostate cancer (PCa), particularly metastatic PCa. The mechanisms underlying these …