The importance of developmental factors in influencing the risk of later-life disease has a
strong evidence base derived from multiple epidemiological, clinical and experimental …

Cellular commitment to a specific lineage is controlled by differential silencing of genes,
which in turn depends on epigenetic processes such as DNA methylation and histone …

The cardiovascular system is responsible for transport of blood and nutrients to tissues, and
is pivotal to the physiological health and longevity. Epigenetic modification is a natural, age …

There is ample evidence that subtle changes in the early environment, not restricted to the
fetal period but expanded to the plastic phase of early development, influence adulthood …

There is now evidence that developmental influences have lifelong effects on cardiovascular
and metabolic function and that elements of the heritable or familial component of …

Epidemiological and animal studies show that small changes in the developmental
environment can induce phenotypic changes affecting an individual's responses to their …

The unrelenting rise in global rates of non-communicable disease has necessitated a
thorough re-evaluation of the current use of adult-and lifestyle-based strategies to curb the …

Epigenetics has the potential to explain various biological phenomena that have heretofore
defied complete explication. This review describes the various types of endogenous human …

It has become clear that in addition to the DNA sequence there is another layer of
information, termed epigenetic modifications, that can influence phenotypes and traits. In …

A wide range of developmental, nutritional, environmental, and social factors affect the
biological activities of epigenetic mechanisms. These factors change spatiotemporal …