Bioprintable lung extracellular matrix hydrogel scaffolds for 3D culture of mesenchymal stromal cells

B Falcones, H Sanz-Fraile, E Marhuenda, I Mendizábal… - Polymers, 2021 - mdpi.com
Mesenchymal stromal cell (MSC)-based cell therapy in acute respiratory diseases is based
on MSC secretion of paracrine factors. Several strategies have proposed to improve this are …

Development and characterization of a naturally derived lung extracellular matrix hydrogel

RA Pouliot, PA Link, NS Mikhaiel… - … research Part A, 2016 - Wiley Online Library
The complexity and rapid clearance mechanisms of lung tissue make it difficult to develop
effective treatments for many chronic pathologies. We are investigating lung derived …

Epithelial cell differentiation of human mesenchymal stromal cells in decellularized lung scaffolds

JJ Mendez, M Ghaedi, D Steinbacher… - … Engineering Part A, 2014 - liebertpub.com
Identification of appropriate donor cell types is important for lung cell therapy and for lung
regeneration. Previous studies have indicated that mesenchymal stromal cells derived from …

hLMSC secretome affects macrophage activity differentially depending on lung-mimetic environments

B Falcones, Z Söderlund, A Ibáñez-Fonseca… - Cells, 2022 - mdpi.com
Mesenchymal stromal cell (MSC)-based therapies for inflammatory diseases rely mainly on
the paracrine ability to modulate the activity of macrophages. Despite recent advances, there …

A composite Gelatin/hyaluronic acid hydrogel as an ECM mimic for developing mesenchymal stem cell‐derived epithelial tissue patches

P Kumar, S Ciftci, J Barthes… - Journal of tissue …, 2020 - Wiley Online Library
Here we report fabrication of Gelatin‐based biocomposite films and their application in
developing epithelial patches. The films were loaded with an epithelial cell growth factor …

Harnessing the properties of biomaterial to enhance the immunomodulation of mesenchymal stem cells

Y Chen, Z Shu, K Qian, J Wang… - Tissue Engineering Part B …, 2019 - liebertpub.com
Mesenchymal stem cells (MSCs) have great therapeutic potential for tissue engineering and
regenerative medicine due to their multipotency and paracrine functions. However, shortly …

Intravenous injection of mesenchymal stem cell spheroids improves the pulmonary delivery and prolongs in vivo survival

Y Shimazawa, K Kusamori, M Tsujimura… - Biotechnology …, 2022 - Wiley Online Library
Background Because of the excellent therapeutic potential, mesenchymal stem cells (MSCs)
have been used as cell therapeutics for various diseases. However, the survival rate and …

[HTML][HTML] Persistency of mesenchymal stromal/stem cells in lungs

E Ferrini, FF Stellari, V Franceschi, F Macchi… - Frontiers in cell and …, 2021 - frontiersin.org
Mesenchymal stromal/stem Cells (MSCs) are a fibroblast-like cell population with high
regenerative potential that can be isolated from many different tissues. Several data suggest …

Three-dimensional printing of stem cell-laden hydrogels submerged in a hydrophobic high-density fluid

DFD Campos, A Blaeser, M Weber, J Jäkel… - …, 2012 - iopscience.iop.org
Over the last decade, bioprinting technologies have begun providing important tissue
engineering strategies for regenerative medicine and organ transplantation. The major …

Biofabrication of tissue constructs by 3D bioprinting of cell-laden microcarriers

R Levato, J Visser, JA Planell, E Engel, J Malda… - …, 2014 - iopscience.iop.org
Bioprinting allows the fabrication of living constructs with custom-made architectures by
spatially controlled deposition of multiple bioinks. This is important for the generation of …