NP213 (Novexatin®): A unique therapy candidate for onychomycosis with a differentiated safety and efficacy profile

DK Mercer, JC Robertson, L Miller, CS Stewart… - Medical …, 2020 - academic.oup.com
NP213 (Novexatin®) is a novel antifungal peptide specifically designed for the topical
treatment of onychomycosis. NP213 was designed using host defense peptides (HDP) …

Improved methods for assessing therapeutic potential of antifungal agents against dermatophytes and their application in the development of NP213, a novel …

DK Mercer, CS Stewart, L Miller… - Antimicrobial agents …, 2019 - Am Soc Microbiol
Onychomycosis is a common, difficult-to-treat nail infection that is mainly caused by
dermatophytes. Current therapies are not wholly effective and are associated with manifold …

[PDF][PDF] Clinical evaluation of safety and efficacy of a new topical treatment for onychomycosis

MD Adnan Nasir, MD Beth Goldstein… - Journal of Drugs in …, 2011 - chessonlabs.com
Objective: This clinical study assessed the safety and efficacy of an investigational topical
product for the treatment of onychomycosis (nail fungus). Method: A prospective, multi …

Characterization of antifungal activity and nail penetration of ME1111, a new antifungal agent for topical treatment of onychomycosis

Y Tabata, N Takei-Masuda, N Kubota… - Antimicrobial Agents …, 2016 - Am Soc Microbiol
Fungal nail infection (onychomycosis) is a prevalent disease in many areas of the world,
with a high incidence approaching 23%. Available antifungals to treat the disease suffer …

Novel investigational therapies for onychomycosis: an update

AK Gupta, C Studholme - Expert opinion on investigational drugs, 2016 - Taylor & Francis
Introduction: Onychomycosis is an infection of the nail plate that is prevalent among the
ageing population. Onychomycosis is difficult to treat with low initial cure rates, high rates of …

Novel and investigational treatments for onychomycosis

S Gregoriou, M Kyriazopoulou, A Tsiogka… - Journal of Fungi, 2022 - mdpi.com
Onychomycosis is a common nail disease caused by fungi. The primary pathogens are
dermatophytes; however, yeasts, non-dermatophyte moulds, and mixed fungal populations …

[PDF][PDF] Over-the-counter and natural remedies for onychomycosis: do they really work

P Halteh, RK Scher, SR Lipner - Cutis, 2016 - cdn.mdedge.com
Onychomycosis is divided into different subtypes based on clinical presentation, which in
turn are characterized by varying infecting organisms and prognoses. The subtypes of …

Antifungal agents for onychomycosis: new treatment strategies to improve safety

LT Zane, S Chanda, D Coronado… - Dermatology Online …, 2016 - escholarship.org
Onychomycosis is a common and difficult-to-treat fungal infection of the nail unit that
gradually leads to dystrophic changes of the nail plate and nail bed. If untreated, infection …

Challenges and Opportunities in the Management of Onychomycosis

JK Christenson, GM Peterson, M Naunton, M Bushell… - Journal of Fungi, 2018 - mdpi.com
Onychomycosis is an increasingly common fungal nail infection, chiefly caused by
dermatophyte fungi. The disease is notoriously difficult to treat due to the deep-seated …

Progress on new therapeuties for fungal nail infections

SJ Baker, X Hui, HI Maibach - Annual Reports in Medicinal Chemistry, 2005 - Elsevier
Onychomycosis is a fungal infection of the toe and finger nails, with the majority of cases
involving infection of the toe nails [1]. The disease is mostly caused by a class of fungi …