[HTML][HTML] Failed, interrupted, or inconclusive trials on neuroprotective and neuroregenerative treatment strategies in multiple sclerosis: update 2015–2020
N Huntemann, L Rolfes, M Pawlitzki, T Ruck, S Pfeuffer… - Drugs, 2021 - Springer
In the recent past, a plethora of drugs have been approved for the treatment of multiple
sclerosis (MS). These therapeutics are mainly confined to immunomodulatory or …
sclerosis (MS). These therapeutics are mainly confined to immunomodulatory or …
[HTML][HTML] Failed, interrupted, or inconclusive trials on immunomodulatory treatment strategies in multiple sclerosis: update 2015–2020
L Rolfes, M Pawlitzki, S Pfeuffer, N Huntemann… - BioDrugs, 2020 - Springer
In the past decades, multiple sclerosis (MS) treatment has experienced vast changes
resulting from major advances in disease-modifying therapies (DMT). Looking at the overall …
resulting from major advances in disease-modifying therapies (DMT). Looking at the overall …
Failed, interrupted and inconclusive trials on relapsing multiple sclerosis treatment: update 2010–2015
S Pfeuffer, T Ruck, C Kleinschnitz… - Expert Review of …, 2016 - Taylor & Francis
The treatment of multiple sclerosis (MS) remains challenging despite the great efforts made
in the development of novel therapies. Driven by the growing knowledge of the …
in the development of novel therapies. Driven by the growing knowledge of the …
Current status of neuroprotective and neuroregenerative strategies in multiple sclerosis: A systematic review
JR Allanach, JW Farrell III, M Mésidor… - Multiple Sclerosis …, 2022 - journals.sagepub.com
Background: Immune-mediated demyelination and consequent degeneration of
oligodendrocytes and axons are hallmark features of multiple sclerosis (MS). Remyelination …
oligodendrocytes and axons are hallmark features of multiple sclerosis (MS). Remyelination …
Updates and advances in multiple sclerosis neurotherapeutics
The multiple sclerosis (MS) neurotherapeutic landscape is rapidly evolving. New disease-
modifying therapies (DMTs) with improved efficacy and safety, in addition to an expanding …
modifying therapies (DMTs) with improved efficacy and safety, in addition to an expanding …
Neuroprotection, regeneration and immunomodulation: broadening the therapeutic repertoire in multiple sclerosis
O Aktas, B Kieseier, HP Hartung - Trends in neurosciences, 2010 - cell.com
Multiple sclerosis (MS), an incurable but manageable disorder, is characterized by chronic
inflammatory demyelination and neurodegeneration in the central nervous system. Although …
inflammatory demyelination and neurodegeneration in the central nervous system. Although …
Therapies for multiple sclerosis: translational achievements and outstanding needs
A Haghikia, R Hohlfeld, R Gold, L Fugger - Trends in Molecular Medicine, 2013 - cell.com
In recent years, multiple sclerosis (MS) research has progressed on several fronts,
prompting numerous clinical trials, primarily for immunotherapeutics. Although several new …
prompting numerous clinical trials, primarily for immunotherapeutics. Although several new …
Current and emerging disease‐modulatory therapies and treatment targets for multiple sclerosis
F Piehl - Journal of Internal Medicine, 2021 - Wiley Online Library
The treatment of multiple sclerosis (MS), the most common chronic inflammatory,
demyelinating and neurodegenerative disease of the central nervous system (CNS) …
demyelinating and neurodegenerative disease of the central nervous system (CNS) …
New targets and therapeutics for neuroprotection, remyelination and repair in multiple sclerosis
P Villoslada, L Steinman - Expert opinion on investigational drugs, 2020 - Taylor & Francis
Introduction Immunotherapies for multiple sclerosis (MS) significantly decrease the risk of
new relapses. However, the chronic compartmentalized inflammation and …
new relapses. However, the chronic compartmentalized inflammation and …
Achievements and obstacles of remyelinating therapies in multiple sclerosis
M Stangel, T Kuhlmann, PM Matthews… - Nature Reviews …, 2017 - nature.com
Remyelination in the CNS is the natural process of damage repair in demyelinating
diseases such as multiple sclerosis (MS). However, remyelination becomes inadequate in …
diseases such as multiple sclerosis (MS). However, remyelination becomes inadequate in …