[HTML][HTML] Failed, interrupted, or inconclusive trials on neuroprotective and neuroregenerative treatment strategies in multiple sclerosis: update 2015–2020

N Huntemann, L Rolfes, M Pawlitzki, T Ruck, S Pfeuffer… - Drugs, 2021 - Springer
In the recent past, a plethora of drugs have been approved for the treatment of multiple
sclerosis (MS). These therapeutics are mainly confined to immunomodulatory or …

[HTML][HTML] Failed, interrupted, or inconclusive trials on immunomodulatory treatment strategies in multiple sclerosis: update 2015–2020

L Rolfes, M Pawlitzki, S Pfeuffer, N Huntemann… - BioDrugs, 2020 - Springer
In the past decades, multiple sclerosis (MS) treatment has experienced vast changes
resulting from major advances in disease-modifying therapies (DMT). Looking at the overall …

Failed, interrupted and inconclusive trials on relapsing multiple sclerosis treatment: update 2010–2015

S Pfeuffer, T Ruck, C Kleinschnitz… - Expert Review of …, 2016 - Taylor & Francis
The treatment of multiple sclerosis (MS) remains challenging despite the great efforts made
in the development of novel therapies. Driven by the growing knowledge of the …

Current status of neuroprotective and neuroregenerative strategies in multiple sclerosis: A systematic review

JR Allanach, JW Farrell III, M Mésidor… - Multiple Sclerosis …, 2022 - journals.sagepub.com
Background: Immune-mediated demyelination and consequent degeneration of
oligodendrocytes and axons are hallmark features of multiple sclerosis (MS). Remyelination …

Updates and advances in multiple sclerosis neurotherapeutics

M Amin, CM Hersh - Neurodegenerative disease management, 2023 - Taylor & Francis
The multiple sclerosis (MS) neurotherapeutic landscape is rapidly evolving. New disease-
modifying therapies (DMTs) with improved efficacy and safety, in addition to an expanding …

Neuroprotection, regeneration and immunomodulation: broadening the therapeutic repertoire in multiple sclerosis

O Aktas, B Kieseier, HP Hartung - Trends in neurosciences, 2010 - cell.com
Multiple sclerosis (MS), an incurable but manageable disorder, is characterized by chronic
inflammatory demyelination and neurodegeneration in the central nervous system. Although …

Therapies for multiple sclerosis: translational achievements and outstanding needs

A Haghikia, R Hohlfeld, R Gold, L Fugger - Trends in Molecular Medicine, 2013 - cell.com
In recent years, multiple sclerosis (MS) research has progressed on several fronts,
prompting numerous clinical trials, primarily for immunotherapeutics. Although several new …

Current and emerging disease‐modulatory therapies and treatment targets for multiple sclerosis

F Piehl - Journal of Internal Medicine, 2021 - Wiley Online Library
The treatment of multiple sclerosis (MS), the most common chronic inflammatory,
demyelinating and neurodegenerative disease of the central nervous system (CNS) …

New targets and therapeutics for neuroprotection, remyelination and repair in multiple sclerosis

P Villoslada, L Steinman - Expert opinion on investigational drugs, 2020 - Taylor & Francis
Introduction Immunotherapies for multiple sclerosis (MS) significantly decrease the risk of
new relapses. However, the chronic compartmentalized inflammation and …

Achievements and obstacles of remyelinating therapies in multiple sclerosis

M Stangel, T Kuhlmann, PM Matthews… - Nature Reviews …, 2017 - nature.com
Remyelination in the CNS is the natural process of damage repair in demyelinating
diseases such as multiple sclerosis (MS). However, remyelination becomes inadequate in …