Alzheimer's disease causes a progressive dementia that currently affects over 35 million
individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no …

Abstract Changes to lipid metabolism are tightly associated with the onset and pathology of
Alzheimer's disease (AD). Lipids are complex molecules comprising many isomeric and …

To facilitate clinical trials of disease-modifying therapies for Alzheimer's disease, which are
expected to be most efficacious at the earliest and mildest stages of the disease,, supportive …

Comorbidities confound Alzheimer’s blood tests | Nature Medicine Skip to main content Thank
you for visiting nature.com. You are using a browser version with limited support for CSS. To …

We recently documented plasma lipid dysregulation in preclinical late-onset Alzheimer's
disease (LOAD). A 10 plasma lipid panel, predicted phenoconversion and provided 90 …

Alzheimer's disease (AD) is reported to be closely linked with abnormal lipid metabolism. To
gain a more comprehensive understanding of what causes AD and its subsequent …

The brain is highly enriched in lipids, and an intensive study of these lipids may be
informative, not only of normal brain function but also of changes with age and in disease. In …

APOE4 is the strongest genetic risk factor for Alzheimer's disease,–. However, the effects of
APOE4 on the human brain are not fully understood, limiting opportunities to develop …

Introduction The absolute quantitation of lipids at the lipidome-wide scale is a challenge but
plays an important role in the comprehensive study of lipid metabolism. Objectives We aim …

Several genetic risk factors for Alzheimer's disease implicate genes involved in lipid
metabolism and many of these lipid genes are highly expressed in glial cells. However, the …