The liver orchestrates systemic iron balance by producing and secreting hepcidin. Known as
the iron hormone, hepcidin induces degradation of the iron exporter ferroportin to control …

The iron-regulatory hormone hepcidin is a 25–amino acid peptide that is synthesized in
hepatocytes. Hepcidin binds to the cellular iron export channel ferroportin and causes its …

Iron is a micronutrient essential for almost all organisms: bacteria, plants, and animals. It is a
metal that exists in multiple redox states, including the divalent ferrous (Fe2+) and the …

The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the
major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron …

Under evolutionary pressure to counter the toxicity of iron and to maintain adequate iron
supply for hemoglobin synthesis and essential metabolic functions, humans and other …

Although most circulating iron in blood plasma is destined for erythropoiesis, the
mechanisms by which erythropoietic demand modulates the iron supply (“erythroid …

Systemic iron homeostasis depends on the regulated expression of hepcidin, a peptide
hormone that negatively regulates iron egress from intestinal cells and macrophages by …

Despite fluctuations in dietary iron intake and intermittent losses through bleeding, the
plasma iron concentrations in humans remain stable at 10–30μM. While most of the iron …

Iron, an essential nutrient, is required for many biological processes but is also toxic in
excess. The lack of a mechanism to excrete excess iron makes it crucial for the body to …

The regulation of iron metabolism in biological systems centers on providing adequate iron
for cellular function while limiting iron toxicity. Because mammals cannot excrete iron …