Objective Previous studies reported the associations between the ATP-binding cassette sub-
family B member 1 (ABCB1, also known as MDR1) polymorphisms and their haplotypes with …

been satisfied for the transporter hypothesis, however, only in rodent models of epilepsy as
yet [7]. Accordingly, P-gp expression is: increased in epileptogenic brain tissue of rodents; …

Background: Approximately one‐third of patients with epilepsy patients have recurrent
seizures despite therapy. It has been suggested that therapeutic failure is associated with …

Purpose A synonymous C to T variant at position 3435 (c. 3435C> T) is one common
polymorphism of the multidrug resistant 1 (MDR1) gene, which encodes the major …

Purpose Epilepsy is a common serious brain condition characterized by the abnormal
electrical activity of neurons. In most cases, epileptic patients respond to antiepileptic drugs …

Abstract Background Antiepileptic drugs (AEDs) are effective medications available for
epilepsy. However, many patients do not respond to this treatment and become resistant …

Previous studies have attempted to confirm the association between the ABCB1-C3435T
polymorphism and drug-resistant epilepsy and produced discordant findings. A meta …

Drug-resistant epilepsy is also referred to as intractable, medically refractory, or
pharmacoresistant epilepsy. Approximately, one-third of patients with epilepsy have …

OBJECTIVE: The C3435T, a major allelic variant of the ABCB1 gene, is proposed to play a
crucial role in drug-resistance in epilepsy. The C/C genotype carriers reportedly are at …

The association between the C3435T polymorphism in the MDR1 gene and refractory
epilepsy remains controversial. The association appears to be influenced by ethnicity and …