The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Ionotropic glutamate receptors are ligand-gated ion channels that mediate rapid information
transfer at most excitatory synapses in the brain. Crystal structures are now available for the …

As in the case of many ligand-gated ion channels, the biochemical and electrophysiological
properties of the ionotropic glutamate receptors have been studied extensively …

In native brain membranes the principal excitatory neurotransmitter L-glutamate activates
cation-conducting channels with distinct biophysical and pharmacological properties …

Glutamate receptor ion channels mediate excitatory responses at the majority of CNS
synapses. They are the only ligand-gated ion channels for which multiple high-resolution …

X-ray crystal structures for the soluble amino-terminal and ligand-binding domains of
glutamate receptor ion channels, combined with a 3.6-Å-resolution structure of the full-length …

Exciting new milestones in glutamate receptor (GluR) channel research include the
following: the cloning of N-methyl-d-aspartate (NMDA) receptors; delineation of molecular …

▪ Abstract A vast number of proteins are involved in synaptic function. Many have been
cloned and their functional role defined with varying degrees of success, but their number …

Glutamate receptors are critically important for normal brain function. The preceding decade
has seen remarkable advances in our understanding of the physiological function and …