There is an urgent need to validate new drug targets and identify small molecules that
possess activity against both drug-resistant and drug-sensitive bacteria. The enzymes …

Homoserine transacetylase (HTA) catalyzes the transfer of an acetyl group from acetyl-CoA
to the hydroxyl group of homoserine. This is the first committed step in the biosynthesis of …

Mycobacterium tuberculosis is the cause of the world's most deadly infectious disease.
Efforts are underway to target the methionine biosynthesis pathway, as it is not part of the …

Mycobacterium tuberculosis (Mtb) lacking functional homoserine transacetylase (HTA) is
compromised in methionine biosynthesis, protein synthesis, and in the activity of multiple …

In ϒ-proteobacteria and Actinomycetales, cysteine biosynthetic enzymes are indispensable
during persistence and become dispensable during growth or acute infection. The …

Abstract l-cysteine, a primary building block of mycothiol, plays an essential role in the
defense mechanism of Mycobacterium tuberculosis (Mtb). However, it is unclear how Mtb …

Microbial amino acid biosynthesis is a proven yet underexploited target of antibiotics. The
biosynthesis of methionine in particular has been shown to be susceptible to small-molecule …

Infectious diseases have been jeopardized problem that threaten public health over a long
period of time. The growing prevalence of drug‐resistant pathogens and infectious cases …

Mycobacterium smegmatis is a good model for studying the physiology and pathogenesis of
Mycobacterium tuberculosis due to its genetic similarity. As methionine biosynthesis exists …

Microbial amino acid biosynthetic pathways are underexploited for the development of anti-
bacterial agents. N-acetyl glutamate synthase (ArgA) catalyses the first committed step in L …