Cell-type-specific gene expression is physiologically modulated by the binding of
transcription factors to genomic enhancer sequences, to which chromatin modifiers such as …

Histone deacetylases (HDACs) are believed to regulate gene transcription by catalyzing
deacetylation reactions. HDAC3 depletion in mouse liver upregulates lipogenic genes and …

Abstract Histone deacetylase 3 (HDAC3) is an epigenome-modifying enzyme that is
required for normal mouse development and tissue-specific functions. In vitro, HDAC3 …

HDAC1 and-2 are highly conserved enzymes and often coexist in the same coregulator
complexes. Understanding the regulation of histone deacetylase activities is extremely …

Histone deacetylases (HDACs) are part of transcriptional corepressor complexes and play
key roles in regulating chromatin structure. Three different classes of human HDACs have …

Although histone deacetylases (HDACs) are generally viewed as corepressors, we show
that HDAC1 serves as a coactivator for the glucocorticoid receptor (GR). Furthermore, a …

HDACs (histone deacetylases) 1 and 2 are ubiquitous long-lived proteins, which are often
found together in three major multiprotein co-repressor complexes: Sin3, NuRD …

Acetylation and deacetylation of nucleosomal histones have profound effects on gene
transcription in all eukaryotes. In humans, three highly homologous class I and four class II …

Accessibility of the genome to DNA-binding transcription factors is regulated by proteins that
control the acetylation of amino-terminal lysine residues on nucleosomal histones …

Known histone deacetylases (HDACs) are divided into different classes, and HDAC3
belongs to Class I. Through forming multiprotein complexes with the corepressors SMRT …