Spontaneous tumors in canines share significant genetic and histological similarities with
human tumors, positioning them as valuable models to guide drug development. However …

Naturally occurring canine cancers have remarkable similarities to their human counterparts.
To better understand these similarities, we investigated 671 client-owned dogs from 96 …

Spontaneous canine cancers are valuable but relatively understudied and underutilized
models. To enhance their usage, we reanalyze whole exome and genome sequencing data …

Background Growing evidence from dogs and humans supports the abundance of mutation‐
based biomarkers in tumors of dogs. Increasing the use of clinical genomic diagnostic …

Pet dogs develop spontaneous cancers at a rate estimated to be five times higher than that
of humans, providing a unique opportunity to study disease biology and evaluate novel …

Background Molecularly-guided trials (ie PMed) now seek to aid clinical decision-making by
matching cancer targets with therapeutic options. Progress has been hampered by the lack …

Dogs are remarkable, adaptable, and dependable creatures that have evolved alongside
humans while contributing tremendously to our survival. Our canine companions share …

The natural world brings to us an array of opportunities to understand the processes of life
and disease. Naturally occurring or spontaneous diseases of animals allow us to gain …

Spontaneous cancers in client-owned dogs closely recapitulate their human counterparts
with respect to clinical presentation, histological features, molecular profiles, and response …

Despite a considerable expenditure of time and resources and significant advances in
experimental models of disease, cancer research continues to suffer from extremely low …