Material solutions for delivery of CRISPR/Cas-based genome editing tools: Current status and future outlook

T Wan, D Niu, C Wu, FJ Xu, G Church, Y Ping - Materials Today, 2019 - Elsevier
Clustered regularly interspaced short palindromic repeat (CRISPR)/associated protein
(CRISPR/Cas) system is an adaptable immune mechanism used by many bacteria to protect …

Carrier strategies boost the application of CRISPR/Cas system in gene therapy

Z Xu, Q Wang, H Zhong, Y Jiang, X Shi, B Yuan… - …, 2022 - Wiley Online Library
Emerging clustered regularly interspaced short palindromic repeat/associated protein
(CRISPR/Cas) genome editing technology shows great potential in gene therapy. However …

Delivery of CRISPR/Cas9 by novel strategies for gene therapy

L Wang, W Zheng, S Liu, B Li, X Jiang - ChemBioChem, 2019 - Wiley Online Library
Precise editing of the genome of a living body is a goal pursued by scientists in many fields.
In recent years, CRISPR (clustered regularly interspaced short palindromic repeat)/Cas …

Non-viral delivery systems for CRISPR/Cas9-based genome editing: Challenges and opportunities

L Li, S Hu, X Chen - Biomaterials, 2018 - Elsevier
In recent years, CRISPR (clustered regularly interspaced short palindromic repeat)/Cas
(CRISPR-associated) genome editing systems have become one of the most robust …

Delivering the CRISPR/Cas9 system for engineering gene therapies: Recent cargo and delivery approaches for clinical translation

RA Foley, RA Sims, EC Duggan, JK Olmedo… - … in Bioengineering and …, 2022 - frontiersin.org
Clustered Regularly Interspaced Short Palindromic Repeats associated protein 9
(CRISPR/Cas9) has transformed our ability to edit the human genome selectively. This …

Engineering the delivery system for CRISPR-based genome editing

Z Glass, M Lee, Y Li, Q Xu - Trends in biotechnology, 2018 - cell.com
Clustered regularly interspaced short palindromic repeat-CRISPR-associated protein
(CRISPR-Cas) systems, found in nature as microbial adaptive immune systems, have been …

CRISPR/Cas9 delivery system engineering for genome editing in therapeutic applications

H Cheng, F Zhang, Y Ding - Pharmaceutics, 2021 - mdpi.com
The clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein
9 (CRISPR/Cas9) systems have emerged as a robust and versatile genome editing platform …

Synthetic multi-layer nanoparticles for CRISPR-Cas9 genome editing

H Tang, X Zhao, X Jiang - Advanced drug delivery reviews, 2021 - Elsevier
The clustered regularly interspaced short palindromic repeat (CRISPR) has great potential
to revolutionize biomedical research and disease therapy. The specific and efficient genome …

Rational designs of in vivo CRISPR-Cas delivery systems

CF Xu, GJ Chen, YL Luo, Y Zhang, G Zhao… - Advanced drug delivery …, 2021 - Elsevier
The CRISPR-Cas system initiated a revolution in genome editing when it was, for the first
time, demonstrated success in the mammalian cells. Today, scientists are able to readily edit …

Pre-clinical non-viral vectors exploited for in vivo CRISPR/Cas9 gene editing: An overview

N Rouatbi, T McGlynn, KT Al-Jamal - Biomaterials Science, 2022 - pubs.rsc.org
Clustered regulatory interspaced short palindromic repeats or CRISPR/Cas9 has emerged
as a potent and versatile tool for efficient genome editing. This technology has been …