Oxidative stress has been proven to be related to the onset of a large number of health
disorders. This chemical stress is triggered by an excess of free radicals, which are …

Melatonin is a potent endogenous free radical scavenger, actions that are independent of its
many receptor-mediated effects. In the last several years, hundreds of publications have …

Oxidative stress (OS) represents a threat to the chemical integrity of biomolecules including
lipids, proteins, and DNA. The associated molecular damage frequently results in serious …

This review aims at describing the beneficial properties of melatonin related to its antioxidant
effects. Oxidative stress, ie, an imbalance between the production of reactive oxygen …

Melatonin was found to be a potent free radical scavenger in 1993. Since then over 800
publications have directly or indirectly confirmed this observation. Melatonin scavenges a …

Oxygen is used by eukaryotic cells for metabolic transformations and energy production in
mitochondria. Under physiological conditions, there is a constant endogenous production of …

Melatonin is an endogenous hormone derived from tryptophan that is mainly released from
the pineal gland in the dark. Melatonin regulates many biological functions such as sleep …

In recent years, relationship between free radicals and oxidative stress with aging, cancer,
atherosclerosis, neurodegenerative disorders, diabetes, and inflammatory diseases became …

Melatonin has been shown to be an effective antioxidant in a number of experimental
models both in vitro and in vivo. Considering the data available, it is now clear that the …

Melatonin is uncommonly effective in reducing oxidative stress under a remarkably large
number of circumstances. It achieves this action via a variety of means: direct detoxification …