The purpose of this report is to review the relationship between genetic polymorphisms
involved in carcinogen metabolism, alcohol metabolism and cell-cycle control with the risk of …

BACKGROUND: Heavy alcohol consumption increases risk of developing squamous cell
carcinoma of the head and neck (SCCHN). Alcohol metabolism to cytotoxic and mutagenic …

Background The Basque Country has one of the highest rates of head and neck squamous
cell carcinoma (HNSCC) in Europe, although tobacco and alcohol consumption are not high …

Background: Single-nucleotide polymorphisms (SNP) in alcohol metabolism genes are
associated with squamous cell carcinoma of the head and neck (SCCHN) and may …

Purpose As risk-modifiers of alcohol and tobacco effects, metabolic genes polymorphisms
were investigated as susceptibility candidates for squamous cell carcinoma of the head and …

Aim s: The incidence of head and neck cancer (HNC) in Brazil has increased substantially in
recent years. This increase is likely to be strongly associated with alcohol and tobacco …

Alcohol consumption is a strong risk factor for squamous cell carcinoma of the head and
neck (SCCHN). The genetic polymorphisms aldehyde dehydrogenase2 (ALDH2) Glu487Lys …

Objective. Several studies have suggested that the metabolism of alcohol is modulated by
the polymorphisms in genes encoding ethanol-metabolizing enzymes, including alcohol …

BACKGROUND: The authors conducted a hospital‐based study of 1110 patients with
squamous cell carcinoma of the head and neck (SCCHN) and a control group of 1129 …

Alcohol consumption is a major risk factor for squamous cell carcinoma of the head and
neck (SCCHN). Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are …