In the ancient anaerobic environment, ferrous iron (Fe2+) was one of the first metal
cofactors. Oxygenation of the ancient world challenged bacteria to acquire the insoluble …

Control of metal homeostasis is essential for life in all kingdoms. In most prokaryotic
organisms the FUR (ferric uptake regulator) family of transcriptional regulators is involved in …

The ferric-uptake regulator (Fur) is an Fe2+-responsive transcription factor that coordinates
iron homeostasis in many bacteria. Recently, we reported that expression of the Escherichia …

Proteins belonging to the FUR (ferric uptake regulator) family are the cornerstone of
metalloregulation in most prokaryotes. Although numerous reviews have been devoted to …

Significance: Iron is required for growth and is often redox active under cytosolic conditions.
As a result of its facile redox chemistry, iron homeostasis is intricately involved with oxidative …

It is generally accepted that iron is the most important micronutrient used by bacteria. With
members of the family Lactobacillae being the only exceptions so far (3), this metal is …

The ferric uptake regulator (Fur) plays a critical role in the transcriptional regulation of iron
metabolism. However, the full regulatory potential of Fur remains undefined. Here we …

In bacteria–host interactions, competition for iron is critical for the outcome of the infection.
As a result of its redox properties, this metal is essential for the growth and proliferation of …

The ferric uptake regulator (Fur) protein, as originally described in Escherichia coli, is an iron-
sensing repressor that controls the expression of genes for siderophore biosynthesis and …

The ferric uptake regulator (Fur) is a global transcription factor that regulates intracellular
iron homeostasis in bacteria. The current hypothesis states that when the intracellular" free" …