Cancer-associated fibroblasts (CAF) are a poorly characterized cell population in the context
of liver cancer. Our study investigates CAF functions in intrahepatic cholangiocarcinoma …

Primary liver cancer (PLC) includes hepatocellular carcinoma and intrahepatic
cholangiocarcinoma and is the sixth most common cancer worldwide with poor prognosis …

The hepatic stellate cells in the liver are stimulated sustainably by chronic injury of the
hepatocytes, activating myofibroblasts, which produce abundant collagen. Myofibroblasts …

Liver fibrosis is a substantial risk factor for the development and progression of liver cancer,
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …

Liver cancer is the second leading cause of cancer mortality worldwide, causing more than
700,000 deaths annually. Because of the wide landscape of genomic alterations and limited …

The tumor microenvironment (TME) is a complex multicellular functional compartment that
includes fibroblasts, myofibroblasts, endothelial cells, immune cells, and extracellular matrix …

Background and Aims Cancer‐associated fibroblasts (CAFs) are key players in multicellular,
stromal‐dependent alterations leading to HCC pathogenesis. However, the intricate …

The roles of cancer‐associated fibroblasts (CAF) in the progression of various types of
cancers are well established. CAF promote cancer progression through pleiotropic …

Background & Aims Cancer-associated fibroblasts (CAFs) play a key role in the cancer
process, but the research progress is hampered by the paucity of preclinical models that are …

Hepatocellular carcinoma (HCC) is a lethal disease, and recurrence and metastasis are the
major causes of death in HCC patients. Cancer-associated fibroblasts (CAFs), a major …