Loss of MeCP2 in adult 5-HT neurons induces 5-HT1A autoreceptors, with opposite sex-dependent anxiety and depression phenotypes
The 5-HT1A autoreceptor mediates feedback inhibition of serotonin (5-HT) neurons, and is
implicated in major depression. The human 5-HT1A gene (HTR1A) rs6295 risk allele …
implicated in major depression. The human 5-HT1A gene (HTR1A) rs6295 risk allele …
Sex-dependent adaptive changes in serotonin-1A autoreceptor function and anxiety in Deaf1-deficient mice
C Luckhart, TJ Philippe, B Le François, F Vahid-Ansari… - Molecular Brain, 2016 - Springer
Abstract The C (-1019) G rs6295 promoter polymorphism of the serotonin-1A (5-HT1A)
receptor gene is associated with major depression in several but not all studies, suggesting …
receptor gene is associated with major depression in several but not all studies, suggesting …
Increased serotonin-1A (5-HT1A) autoreceptor expression and reduced raphe serotonin levels in deformed epidermal autoregulatory factor-1 (Deaf-1) gene knock-out …
M Czesak, B Le François, AM Millar, M Deria… - Journal of Biological …, 2012 - ASBMB
Altered regulation of the serotonin-1A (5-HT1A) receptor gene is implicated in major
depression and mood disorders. The functional human 5-HT1A C (− 1019) G promoter …
depression and mood disorders. The functional human 5-HT1A C (− 1019) G promoter …
Cell-specific repressor or enhancer activities of Deaf-1 at a serotonin 1A receptor gene polymorphism
M Czesak, S Lemonde, EA Peterson… - Journal of …, 2006 - Soc Neuroscience
The serotonin-1A (5-HT1A) receptor is the primary somatodendritic autoreceptor that inhibits
the activity of serotonergic raphe neurons and is also expressed in nonserotonergic cortical …
the activity of serotonergic raphe neurons and is also expressed in nonserotonergic cortical …
Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness
PR Albert, B Le François, AM Millar - Molecular brain, 2011 - Springer
Abstract The serotonin-1A (5-HT1A) receptor is among the most abundant and widely
distributed 5-HT receptors in the brain, but is also expressed on serotonin neurons as an …
distributed 5-HT receptors in the brain, but is also expressed on serotonin neurons as an …
Chronic mild stress and antidepressant treatment alter 5-HT1A receptor expression by modifying DNA methylation of a conserved Sp4 site
B Le François, J Soo, AM Millar, M Daigle… - Neurobiology of …, 2015 - Elsevier
Abstract The serotonin 1A receptor (5-HT1A), a critical regulator of the brain serotonergic
tone, is implicated in major depressive disorder (MDD) where it is often found to be dys …
tone, is implicated in major depressive disorder (MDD) where it is often found to be dys …
Transcriptional regulation of the 5-HT1A receptor: implications for mental illness
PR Albert - … Transactions of the Royal Society B …, 2012 - royalsocietypublishing.org
The serotonin-1A (5-HT1A) receptor is an abundant post-synaptic 5-HT receptor
(heteroreceptor) implicated in regulation of mood, emotion and stress responses and is the …
(heteroreceptor) implicated in regulation of mood, emotion and stress responses and is the …
Transcriptional Regulation of the Human 5-HT1A Receptor Gene by Lithium: Role of Deaf1 and GSK3β
EF Harkin, G Nasrallah, B Le François… - International Journal of …, 2023 - mdpi.com
Serotonin 1A (5-HT1A) autoreceptors located on serotonin neurons inhibit their activity, and
their upregulation has been implicated in depression, suicide and resistance to …
their upregulation has been implicated in depression, suicide and resistance to …
Functional interrogation of a depression-related serotonergic single nucleotide polymorphism, rs6295, using a humanized mouse model
AM Cunningham, TL Santos, VA Gutzeit… - ACS chemical …, 2019 - ACS Publications
The serotonin 1A receptor (5-HT1A) system has been extensively implicated in modulating
mood and behavior. Notably, 5-HT1A levels in humans display remarkable variation, and …
mood and behavior. Notably, 5-HT1A levels in humans display remarkable variation, and …
Genetic, epigenetic and posttranscriptional mechanisms for treatment of major depression: the 5-HT1A receptor gene as a paradigm
PR Albert, B Le François, F Vahid-Ansari - Journal of psychiatry and …, 2019 - jpn.ca
Major depression and anxiety are highly prevalent and involve chronic dysregulation of
serotonin, but they remain poorly understood. Here, we review novel transcriptional (genetic …
serotonin, but they remain poorly understood. Here, we review novel transcriptional (genetic …