Application of cardiac molecular imaging using positron emission tomography in evaluation of drug and therapeutics for cardiovascular disorders

K Yoshinaga, BJW Chow, RA dekemp… - Current …, 2005 - ingentaconnect.com
The incidence of cardiovascular disease is increasing with the aging population. This has
stimulated a need for innovative means to evaluate and develop therapeutic strategies …

The role of cardiac PET in translating basic science into the clinical arena

PE Bravo, FM Bengel - Journal of cardiovascular translational research, 2011 - Springer
Non-invasive imaging has become fundamental in translating findings from basic science
research into clinical applications. In this aspect, positron-emission tomography (PET) offers …

PET radiotracers of the cardiovascular system

RJ Gropler - PET clinics, 2009 - Elsevier
Cardiovascular positron emission tomography (PET) provides exquisite measurements of
key aspects of the cardiovascular system and as a consequence it plays central role in …

Evaluation of coronary artery disease with positron emission tomography

M Schwaiger, GD Hutchins - Seminars in nuclear medicine, 1992 - Elsevier
Positron emission tomography (PET) represents the most sophisticated imaging modality in
nuclear medicine allowing quantification of regional tracer tissue concentrations. Beside the …

Utility of positron emission tomography for drug development for heart failure

L Papadimitriou, PM Smith-Jones, CMS Sarwar… - American heart …, 2016 - Elsevier
Only about 1 in 5,000 investigational agents in a preclinical stage acquires Food and Drug
Administration approval. Among many reasons for this includes an inefficient transition from …

Positron emission tomographic imaging in drug discovery

KK Ghosh, P Padmanabhan, CT Yang, DCE Ng… - Drug Discovery …, 2022 - Elsevier
Positron emission tomography (PET) is an extensively used nuclear functional imaging
technique, especially for central nervous system (CNS) and oncological disorders. Currently …

Current status and future applications of cardiac receptor imaging with positron emission tomography

M Schäfers, B Riemann, B Levkau… - Nuclear Medicine …, 2002 - journals.lww.com
Cardiac receptors play a major role in the regulation of cardiac function. Their assessment in
various cardiac diseases may be of clinical importance. Although many different non …

Positron emission tomography molecular imaging for drug development

PM Matthews, EA Rabiner, J Passchier… - British journal of …, 2012 - Wiley Online Library
Human in vivo molecular imaging with positron emission tomography (PET) enables a new
kind of 'precision pharmacology', able to address questions central to drug development …

PET and PET/CT in cardiovascular disease

O Gaemperli, PA Kaufmann - Annals of the New York Academy …, 2011 - Wiley Online Library
The present review provides an overview of the role of cardiac positron emission
tomography in the diagnosis and management of cardiovascular disease. It expands on the …

Biomedical positron emission tomography (PET) imaging

S Chua, A Groves - Biomedical Imaging, 2014 - Elsevier
Positron Emission Tomography (PET) is a major functional imaging technique with wide-
ranging applications across the biological sciences and clinical medicine. Its best known …