Pseudomonas aeruginosa is a major cause of nosocomial infections and the leading cause
of chronic lung infections in cystic fibrosis and chronic obstructive pulmonary disease …

The antibiotic ciprofloxacin is used extensively to treat a wide range of infections caused by
the opportunistic pathogen Pseudomonas aeruginosa. Due to its extensive use, the …

Microbes have developed resistance to nearly every antibiotic, yet the steps leading to drug
resistance remain unclear. Here we report a multistage process by which Pseudomonas …

The dynamics of occurrence and the genetic basis of ciprofloxacin resistance were studied
in a long-term evolution experiment (940 generations) in wild-type, reference strain (PAO1) …

Pseudomonas aeruginosa offers substantial therapeutic challenges due to its high intrinsic
resistance to many antibiotics and its propensity to develop mutational and/or adaptive …

The alarming rise of ciprofloxacin-resistant Pseudomonas aeruginosa has been reported in
several clinical studies. Though the mutation of resistance genes and their role in drug …

With few novel antimicrobials in development, resistance to the current selection of
antibiotics increasingly encroaches on our ability to control microbial infections. One …

Sensitization of resistant bacteria to existing antibiotics depends on the identification of
candidate targets whose activities contribute to resistance. Using a transposon insertion …

We studied the mechanism (s) of resistance to ciprofloxacin arising in a clinical strain of
Pseudomonas aeruginosa and in a laboratory-derived isolate of that strain. Higher …

Treatment of infections by Pseudomonas aeruginosa is difficult due to its high intrinsic and
acquired antibiotic resistance. Upon colonization in the human hosts, P. aeruginosa …