Colorectal cancer (CRC) is one of the leading causes of cancer related-deaths. The risk of
development of CRC is complex and multifactorial, and includes disruption of homeostasis …

Colorectal cancer (CRC) is a major cause of cancer-related mortality and morbidity
worldwide. While improved treatments have enhanced overall patient outcome, disease …

Guanylate cyclase C (GUCY2C) is a transmembrane receptor expressed on the luminal
aspect of the intestinal epithelium. Its ligands include bacterial heat-stable enterotoxins …

Obesity has emerged as a principal cause of mortality worldwide, reflecting comorbidities
including cancer risk, particularly in colorectum. Although this relationship is established …

Despite advances in screening and prevention strategies, colorectal cancer (CRC) remains
the second-leading cause of cancer-related death in the United States. Given this continued …

Introduction: Colorectal cancer remains the second leading cause of cancer death in the
United States, underscoring the need for novel therapies. Despite the successes of new …

Introduction Gastrointestinal (GI) cancers account for the second leading cause of cancer-
related deaths in the United States. Guanylyl cyclase C (GUCY2C) is an intestinal signaling …

Obesity is a well-known risk factor for colorectal cancer but precisely how it influences risks
of malignancy remains unclear. During colon cancer development in humans or animals …

Colorectal cancer remains a major cause of mortality in the USA, despite advances in
prevention and screening. Existing therapies focus primarily on generic treatment such as …

The most commonly lost gene products in colorectal carcinogenesis include the paracrine
hormones guanylin and uroguanylin, the endogenous ligands for guanylyl cyclase C (GCC) …