Central glucocorticoid receptor (GR) activity is enhanced following traumatic events, playing
a key role in the stress-related cognitive abnormalities of posttraumatic stress disorder …

Background Stressors activate a wide spectrum of interacting hormonal and neuronal
systems resulting in behavioral and physiological responses, with consequences for the …

In this study, a novel TRI (triple reuptake inhibitors) antidepressant candidate RO-05 (4-[1-[1-
(benzoyloxy) cyclohexyl]-2-(dimethylamino) ethyl]-phenyl benzoate) was investigated in TST …

Background Changes in glucocorticoid receptors (GRs) have been implicated in the
pathogenesis of stress related psychiatric disorders such as depression and post-traumatic …

Aims: To investigate the effect of RU486 (mifepristone) on emotional disorders in chronic
restraint stress-induced rats and to explore the mechanisms of that phenomenon. Methods …

Rationale Since the precise mechanisms of posttraumatic stress disorder (PTSD) remain
unknown, effective treatment interventions have not yet been established. Numerous clinical …

Post-traumatic stress disorder (PTSD) is a stress-related mental disorder caused by
traumatic experience, and presents with characteristic symptoms, such as intrusive …

In the present study, we investigated the effectiveness of GLYX-13, an NMDA receptor
glycine site functional partial agonist, to alleviate the enhanced anxiety and fear response in …

Background Posttraumatic stress disorder (PTSD) is a serious psychiatric condition that was
found to be associated with altered functioning of the hypothalamic-pituitary-adrenal (HPA) …

Icariin, a flavonoid and a major constituent of Herba Epimedii, has been previously
demonstrated to possess potential antidepressant-like effects. In the present study, we …