Liver fibrosis is a reversible pathological process and a wound healing response to liver
injury. As an early stage of various liver diseases, liver fibrosis can develop into cirrhosis …

Salvianolic acid B (Sal B) is a major water soluble component extracted from Radix Salviae
miltiorrhizae, a traditional Chinese herb widely used for treating cardiovascular and hepatic …

Suppression of activation or proliferation, or induction of apoptosis in hepatic stellate cells
(HSCs) have been proposed as therapeutic strategies against liver fibrosis. Salvia …

Introduction and objectives The activation of hepatic stellate cells (HSCs) is the main cause
of liver fibrosis. The beneficial effects of fibroblast growth factor (FGF) 19 on liver fibrosis …

Liver fibrosis is currently a global health challenge with no approved therapy, with the
activation of hepatic stellate cells being a principal factor. Lipophilic constituents in Salvia …

Various isoforms of myocyte enhancer factor 2 (MEF2) have been shown to play a role in the
activation of rat hepatic stellate cells (HSCs) in culture. The signals that regulate MEF2 in …

Platelet-derived growth factor (PDGF) induces cell proliferation together with oxidative
stress. The present study investigated the effects of salvianolic acid A (Sal A) and B (Sal B) …

Background Long non-coding RNA (LncRNAs) have been reported to play an important role
in liver fibrosis and are closely associated with hepatic stellate cell (HSC) activation. We …

The production of reactive oxygen species (ROS) is believed to be involved in liver injury
and hepatic fibrosis. Activation of hepatic stellate cells (HSCs) is a key feature of liver …

In liver fibrosis, transforming growth factor-β1 (TGF-β1) can stimulate autophagy and
activation of hepatic stellate cells (HSCs). Autophagy, playing a crucial role in HSCs …