Ewing sarcoma

TGP Grünewald, F Cidre-Aranaz, D Surdez… - Nature reviews Disease …, 2018 - nature.com
Ewing sarcoma is the second most frequent bone tumour of childhood and adolescence that
can also arise in soft tissue. Ewing sarcoma is a highly aggressive cancer, with a survival of …

EWS/FLI1 target genes and therapeutic opportunities in Ewing sarcoma

F Cidre-Aranaz, J Alonso - Frontiers in oncology, 2015 - frontiersin.org
Ewing sarcoma is an aggressive bone malignancy that affect children and young adults.
Ewing sarcoma is the second most common primary bone malignancy in pediatric patients …

Twenty years on: what do we really know about Ewing sarcoma and what is the path forward?

E Lawlor, PH Sorensen - Critical Reviews™ in Oncogenesis, 2015 - dl.begellhouse.com
Ewing sarcoma (ES) is a highly aggressive bone and soft-tissue tumor with peak incidence
among adolescents and young adults. Despite advances in local control and systemic …

The biology of Ewing sarcoma

N Riggi, I Stamenkovic - Cancer letters, 2007 - Elsevier
Sarcomas account for less than 10% of all human malignancies that are believed to
originate from as yet poorly defined mesenchymal progenitor cells. They constitute some of …

1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma

C Mackintosh, JL Ordonez, DJ Garcia-Dominguez… - Oncogene, 2012 - nature.com
Despite extensive characterization of the role of the EWS-ETS fusions, little is known about
secondary genetic alterations and their clinical contribution to Ewing sarcoma (ES). It has …

Current status of management and outcome for patients with Ewing sarcoma

AC Hesla, A Papakonstantinou, P Tsagkozis - Cancers, 2021 - mdpi.com
Simple Summary Ewing sarcoma is a highly aggressive malignancy affecting primarily
children and adolescents. It is the second most common bone sarcoma among children …

The Genomic Landscape of the Ewing Sarcoma Family of Tumors Reveals Recurrent STAG2 Mutation

AS Brohl, DA Solomon, W Chang, J Wang, Y Song… - PLoS …, 2014 - journals.plos.org
The Ewing sarcoma family of tumors (EFT) is a group of highly malignant small round blue
cell tumors occurring in children and young adults. We report here the largest genomic …

The biology of ewing sarcoma

KA Ross, NA Smyth, CD Murawski… - International Scholarly …, 2013 - Wiley Online Library
Objective. The goal of this study was to review the current literature on the biology of
Ewing′ s sarcoma, including current treatments and the means by which an understanding …

The molecular pathogenesis of Ewing sarcoma

C Mackintosh, J Madoz-Gúrpide… - Cancer biology & …, 2010 - Taylor & Francis
Ewing's sarcoma family tumors (ESFT) are a group of aggressive solid bone and soft tissue
malignancies of children and young adults characterized by specific chromosomal …

Ewing sarcoma: historical perspectives, current state-of-the-art, and opportunities for targeted therapy in the future

JA Ludwig - Current opinion in oncology, 2008 - journals.lww.com
With an improved understanding of the genome, transcriptome, proteome, and other '-
omic'events that promote and sustain Ewing pathogenesis, the use of nascent biologically …